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CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis

Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis and vasculopathy. CXCL4 represents an early serum biomarker of severe SSc and likely contributes to inflammation via chemokine signaling pathways, but the exact role of CXCL4 in SSc pathogenesis is unclear. Here, we e...

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Detalles Bibliográficos
Autores principales:	Lande, Roberto, Lee, Ernest Y., Palazzo, Raffaella, Marinari, Barbara, Pietraforte, Immacolata, Santos, Giancarlo Santiago, Mattenberger, Yves, Spadaro, Francesca, Stefanantoni, Katia, Iannace, Nicoletta, Dufour, Aleksandra Maria, Falchi, Mario, Bianco, Manuela, Botti, Elisabetta, Bianchi, Luca, Alvarez, Montserrat, Riccieri, Valeria, Truchetet, Marie-Elise, C.L. Wong, Gerard, Chizzolini, Carlo, Frasca, Loredana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494823/ https://www.ncbi.nlm.nih.gov/pubmed/31043596 http://dx.doi.org/10.1038/s41467-019-09683-z

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