Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids

Previous studies have utilized monoamine oxidase (MAO) and L-3,4-dihydroxyphenylalanine decarboxylase (DDC) for microbe-based production of tetrahydropapaveroline (THP), a benzylisoquinoline alkaloid (BIA) precursor to opioid analgesics. In the current study, a phylogenetically distinct Bombyx mori...

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Detalles Bibliográficos
Autores principales: Vavricka, Christopher J., Yoshida, Takanobu, Kuriya, Yuki, Takahashi, Shunsuke, Ogawa, Teppei, Ono, Fumie, Agari, Kazuko, Kiyota, Hiromasa, Li, Jianyong, Ishii, Jun, Tsuge, Kenji, Minami, Hiromichi, Araki, Michihiro, Hasunuma, Tomohisa, Kondo, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494836/
https://www.ncbi.nlm.nih.gov/pubmed/31043610
http://dx.doi.org/10.1038/s41467-019-09610-2

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