R406 elicits anti-Warburg effect via Syk-dependent and -independent mechanisms to trigger apoptosis in glioma stem cells

Given that glioma stem cells (GSCs) play a critical role in the initiation and chemoresistance in glioblastoma multiforme (GBM), targeting GSCs is an attractive strategy to treat GBM. Utilizing an anti-cancer compound library, we identified R406, the active metabolite of a FDA-approved Syk inhibitor...

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Detalles Bibliográficos
Autores principales: Sun, Shuxin, Xue, Dongdong, Chen, Zhijie, Ou-yang, Ying, Zhang, Ji, Mai, Jialuo, Gu, Jiayv, Lu, Wanjun, Liu, Xincheng, Liu, Wenfeng, Sheng, Longxiang, Lu, Bingzheng, Lin, Yuan, Xing, Fan, Chen, Zhongping, Mou, Yonggao, Yan, Guangmei, Zhu, Wenbo, Sai, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494878/
https://www.ncbi.nlm.nih.gov/pubmed/31043589
http://dx.doi.org/10.1038/s41419-019-1587-0

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