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Loss of TET2 and TET3 in regulatory T cells unleashes effector function

TET enzymes oxidize 5-methylcytosine to 5-hydroxymethylcytosine and other oxidized methylcytosines in DNA. Here we examine the role of TET proteins in regulatory T (Treg) cells. Tet2/3(fl/fl)Foxp3(Cre) mice lacking Tet2 and Tet3 in Treg cells develop inflammatory disease, and Treg cells from these m...

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Detalles Bibliográficos
Autores principales:	Yue, Xiaojing, Lio, Chan-Wang J., Samaniego-Castruita, Daniela, Li, Xiang, Rao, Anjana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494907/ https://www.ncbi.nlm.nih.gov/pubmed/31043609 http://dx.doi.org/10.1038/s41467-019-09541-y

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