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Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective

Exhaled breath condensate (EBC) was introduced more than two decades ago as a novel, non-invasive tool to assess airway inflammation. This review summarizes the latest literature on the various markers in EBC to predict asthma in children. Despite many recommendations and two comprehensive Task Forc...

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Autores principales: Bannier, Michiel A. G. E., Rosias, Philippe P. R., Jöbsis, Quirijn, Dompeling, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494934/
https://www.ncbi.nlm.nih.gov/pubmed/31106182
http://dx.doi.org/10.3389/fped.2019.00150
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author Bannier, Michiel A. G. E.
Rosias, Philippe P. R.
Jöbsis, Quirijn
Dompeling, Edward
author_facet Bannier, Michiel A. G. E.
Rosias, Philippe P. R.
Jöbsis, Quirijn
Dompeling, Edward
author_sort Bannier, Michiel A. G. E.
collection PubMed
description Exhaled breath condensate (EBC) was introduced more than two decades ago as a novel, non-invasive tool to assess airway inflammation. This review summarizes the latest literature on the various markers in EBC to predict asthma in children. Despite many recommendations and two comprehensive Task Force reports, there is still large heterogeneity in published data. The biggest issue remains a lack of standardization regarding EBC collection, preservation, processing, and analysis. As a result, published studies show mixed or conflicting results, questioning the reproducibility of findings. A joint, multicenter research study is urgently needed to address the necessary methodological standardization.
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spelling pubmed-64949342019-05-17 Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective Bannier, Michiel A. G. E. Rosias, Philippe P. R. Jöbsis, Quirijn Dompeling, Edward Front Pediatr Pediatrics Exhaled breath condensate (EBC) was introduced more than two decades ago as a novel, non-invasive tool to assess airway inflammation. This review summarizes the latest literature on the various markers in EBC to predict asthma in children. Despite many recommendations and two comprehensive Task Force reports, there is still large heterogeneity in published data. The biggest issue remains a lack of standardization regarding EBC collection, preservation, processing, and analysis. As a result, published studies show mixed or conflicting results, questioning the reproducibility of findings. A joint, multicenter research study is urgently needed to address the necessary methodological standardization. Frontiers Media S.A. 2019-04-25 /pmc/articles/PMC6494934/ /pubmed/31106182 http://dx.doi.org/10.3389/fped.2019.00150 Text en Copyright © 2019 Bannier, Rosias, Jöbsis and Dompeling. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Bannier, Michiel A. G. E.
Rosias, Philippe P. R.
Jöbsis, Quirijn
Dompeling, Edward
Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective
title Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective
title_full Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective
title_fullStr Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective
title_full_unstemmed Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective
title_short Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective
title_sort exhaled breath condensate in childhood asthma: a review and current perspective
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494934/
https://www.ncbi.nlm.nih.gov/pubmed/31106182
http://dx.doi.org/10.3389/fped.2019.00150
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