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Pregnancy loss and risk of later dementia: A nationwide cohort study, Denmark, 1977–2017

INTRODUCTION: Pregnancy losses may be associated with increased risks of dementia. METHODS: We conducted a register-based cohort study in 1,243,957 women with ≥1 pregnancy in Denmark in the period 1977–2015. Using Cox regression, we estimated hazard ratios (HRs) comparing risks of dementia in women...

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Detalles Bibliográficos
Autores principales: Basit, Saima, Wohlfahrt, Jan, Boyd, Heather A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495073/
https://www.ncbi.nlm.nih.gov/pubmed/31065584
http://dx.doi.org/10.1016/j.trci.2019.02.006
Descripción
Sumario:INTRODUCTION: Pregnancy losses may be associated with increased risks of dementia. METHODS: We conducted a register-based cohort study in 1,243,957 women with ≥1 pregnancy in Denmark in the period 1977–2015. Using Cox regression, we estimated hazard ratios (HRs) comparing risks of dementia in women with and without pregnancy losses. RESULTS: During 21,672,433 person-years of follow-up, 261,279 women experienced a pregnancy loss, and 2188 women were diagnosed with dementia. Stillbirth was associated with an 86% increased risk of dementia overall (HR 1.86, 95% confidence interval [CI] 1.28–2.71). By contrast, miscarriage was not associated with later risk of dementia overall (single miscarriage, HR 0.99, 95% CI 0.87–1.12; recurrent miscarriages, HR 1.06, 95% CI 0.84–1.35). Adjustment for cardiovascular disease, hypertension, and diabetes did not meaningfully alter the association magnitudes. DISCUSSION: Stillbirth and dementia may share underlying mechanisms, suggesting that a history of stillbirth should be considered when assessing dementia risk in women.