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Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications

Pathogenic organisms may be sensitive to inhibitors of sterol biosynthesis, which carry antimetabolite properties, through manipulation of the key enzyme, sterol methyltransferase (SMT). Here, we isolated natural suicide substrates of the ergosterol biosynthesis pathway, cholesta-5,7,22,24-tetraenol...

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Detalles Bibliográficos
Autores principales:	Zhou, Wenxu, Ramos, Emilio, Zhu, Xunlu, Fisher, Paxtyn M., Kidane, Medhanie E., Vanderloop, Boden H., Thomas, Crista D., Yan, Juqiang, Singha, Ujjal, Chaudhuri, Minu, Nagel, Michael T., Nes, W. David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495176/ https://www.ncbi.nlm.nih.gov/pubmed/30709898 http://dx.doi.org/10.1194/jlr.M091587

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