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Computational Simulations Identified Two Candidate Inhibitors of Cdk5/p25 to Abrogate Tau-associated Neurological Disorders

Deregulation of Cdk5 is a hallmark in neurodegenerative diseases and its complex with p25 forms Cdk5/p25, thereby causes severe neuropathological insults. Cdk5/p25 abnormally phosphorylates tau protein, and induces tau-associated neurofibrillary tangles in neurological disorders. Therefore, the phar...

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Detalles Bibliográficos
Autores principales:	Zeb, Amir, Son, Minky, Yoon, Sanghwa, Kim, Ju Hyun, Park, Seok Ju, Lee, Keun Woo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495220/ https://www.ncbi.nlm.nih.gov/pubmed/31073393 http://dx.doi.org/10.1016/j.csbj.2019.04.010

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