Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness

The global spread of Plasmodium falciparum chloroquine resistance transporter (PfCRT) variant haplotypes earlier caused the widespread loss of chloroquine (CQ) efficacy. In Asia, novel PfCRT mutations that emerged on the Dd2 allelic background have recently been implicated in high-level resistance t...

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Detalles Bibliográficos
Autores principales: Dhingra, Satish K., Gabryszewski, Stanislaw J., Small-Saunders, Jennifer L., Yeo, Tomas, Henrich, Philipp P., Mok, Sachel, Fidock, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495381/
https://www.ncbi.nlm.nih.gov/pubmed/31040246
http://dx.doi.org/10.1128/mBio.02731-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495381/
https://www.ncbi.nlm.nih.gov/pubmed/31040246
http://dx.doi.org/10.1128/mBio.02731-18

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