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A novel neuromodulation strategy to enhance the prefrontal control to treat pain

Effective pharmacological treatment options for chronic pain remain very limited, and continued reliance on opioid analgesics has contributed to an epidemic in the United States. On the other hand, nonpharmacologic neuromodulatory interventions provide a promising avenue for relief of chronic pain w...

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Autores principales: Zhou, Haocheng, Zhang, Qiaosheng, Martinez, Erik, Dale, Jahrane, Robinson, Eric, Huang, Dong, Wang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495436/
https://www.ncbi.nlm.nih.gov/pubmed/31012383
http://dx.doi.org/10.1177/1744806919845739
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author Zhou, Haocheng
Zhang, Qiaosheng
Martinez, Erik
Dale, Jahrane
Robinson, Eric
Huang, Dong
Wang, Jing
author_facet Zhou, Haocheng
Zhang, Qiaosheng
Martinez, Erik
Dale, Jahrane
Robinson, Eric
Huang, Dong
Wang, Jing
author_sort Zhou, Haocheng
collection PubMed
description Effective pharmacological treatment options for chronic pain remain very limited, and continued reliance on opioid analgesics has contributed to an epidemic in the United States. On the other hand, nonpharmacologic neuromodulatory interventions provide a promising avenue for relief of chronic pain without the complications of dependence and addiction. An especially attractive neuromodulation strategy is to optimize endogenous pain regulatory circuits. The prefrontal cortex is known to provide top-down control of pain, and hence neuromodulation methods that selectively enhance the activities in this brain region during pain episodes have the potential to provide analgesia. In this study, we designed a low-frequency (2 Hz) electrical stimulation protocol to provide temporally and spatially specific enhancement of the prefrontal control of pain in rats. We showed that low-frequency electrical stimulation of the prelimbic region of the prefrontal cortex relieved both sensory and affective responses to acute pain in naive rats. Furthermore, we found that low-frequency electrical stimulation of the prefrontal cortex also attenuated mechanical allodynia in a rat model of chronic pain. Together, our findings demonstrated that low-frequency electrical stimulation of the prefrontal cortex represents a promising new method of neuromodulation to inhibit pain.
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spelling pubmed-64954362019-05-08 A novel neuromodulation strategy to enhance the prefrontal control to treat pain Zhou, Haocheng Zhang, Qiaosheng Martinez, Erik Dale, Jahrane Robinson, Eric Huang, Dong Wang, Jing Mol Pain Short Report Effective pharmacological treatment options for chronic pain remain very limited, and continued reliance on opioid analgesics has contributed to an epidemic in the United States. On the other hand, nonpharmacologic neuromodulatory interventions provide a promising avenue for relief of chronic pain without the complications of dependence and addiction. An especially attractive neuromodulation strategy is to optimize endogenous pain regulatory circuits. The prefrontal cortex is known to provide top-down control of pain, and hence neuromodulation methods that selectively enhance the activities in this brain region during pain episodes have the potential to provide analgesia. In this study, we designed a low-frequency (2 Hz) electrical stimulation protocol to provide temporally and spatially specific enhancement of the prefrontal control of pain in rats. We showed that low-frequency electrical stimulation of the prelimbic region of the prefrontal cortex relieved both sensory and affective responses to acute pain in naive rats. Furthermore, we found that low-frequency electrical stimulation of the prefrontal cortex also attenuated mechanical allodynia in a rat model of chronic pain. Together, our findings demonstrated that low-frequency electrical stimulation of the prefrontal cortex represents a promising new method of neuromodulation to inhibit pain. SAGE Publications 2019-05-01 /pmc/articles/PMC6495436/ /pubmed/31012383 http://dx.doi.org/10.1177/1744806919845739 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Short Report
Zhou, Haocheng
Zhang, Qiaosheng
Martinez, Erik
Dale, Jahrane
Robinson, Eric
Huang, Dong
Wang, Jing
A novel neuromodulation strategy to enhance the prefrontal control to treat pain
title A novel neuromodulation strategy to enhance the prefrontal control to treat pain
title_full A novel neuromodulation strategy to enhance the prefrontal control to treat pain
title_fullStr A novel neuromodulation strategy to enhance the prefrontal control to treat pain
title_full_unstemmed A novel neuromodulation strategy to enhance the prefrontal control to treat pain
title_short A novel neuromodulation strategy to enhance the prefrontal control to treat pain
title_sort novel neuromodulation strategy to enhance the prefrontal control to treat pain
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495436/
https://www.ncbi.nlm.nih.gov/pubmed/31012383
http://dx.doi.org/10.1177/1744806919845739
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