Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant Klebsiella pneumoniae

We have identified recombinant human cystatins 9 (rCST9) and C (rCSTC) as a combination immunotherapeutic treatment against multidrug-resistant (MDR) New Delhi metallo-β-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae. We evaluated the lasting protection of rCST9/rCSTC treatment against MDR NDM-...

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Autores principales: Holloway, Alex J., Yu, JiehJuen, Arulanandam, Bernard P., Milligan, Gregg N., Eaves-Pyles, Tonyia D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496045/
https://www.ncbi.nlm.nih.gov/pubmed/30782995
http://dx.doi.org/10.1128/AAC.02519-18
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author Holloway, Alex J.
Yu, JiehJuen
Arulanandam, Bernard P.
Milligan, Gregg N.
Eaves-Pyles, Tonyia D.
author_facet Holloway, Alex J.
Yu, JiehJuen
Arulanandam, Bernard P.
Milligan, Gregg N.
Eaves-Pyles, Tonyia D.
author_sort Holloway, Alex J.
collection PubMed
description We have identified recombinant human cystatins 9 (rCST9) and C (rCSTC) as a combination immunotherapeutic treatment against multidrug-resistant (MDR) New Delhi metallo-β-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae. We evaluated the lasting protection of rCST9/rCSTC treatment against MDR NDM-1 K. pneumoniae pneumonia. Results showed that rCST9/rCSTC treatment modulated endogenous serum biomarkers, cystatins 9 and C and amyloid A, associated with poor patient outcomes and provided prophylactic and long-term protection in a murine model of pneumonia.
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spelling pubmed-64960452019-10-25 Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant Klebsiella pneumoniae Holloway, Alex J. Yu, JiehJuen Arulanandam, Bernard P. Milligan, Gregg N. Eaves-Pyles, Tonyia D. Antimicrob Agents Chemother Experimental Therapeutics We have identified recombinant human cystatins 9 (rCST9) and C (rCSTC) as a combination immunotherapeutic treatment against multidrug-resistant (MDR) New Delhi metallo-β-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae. We evaluated the lasting protection of rCST9/rCSTC treatment against MDR NDM-1 K. pneumoniae pneumonia. Results showed that rCST9/rCSTC treatment modulated endogenous serum biomarkers, cystatins 9 and C and amyloid A, associated with poor patient outcomes and provided prophylactic and long-term protection in a murine model of pneumonia. American Society for Microbiology 2019-04-25 /pmc/articles/PMC6496045/ /pubmed/30782995 http://dx.doi.org/10.1128/AAC.02519-18 Text en Copyright © 2019 Holloway et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Experimental Therapeutics
Holloway, Alex J.
Yu, JiehJuen
Arulanandam, Bernard P.
Milligan, Gregg N.
Eaves-Pyles, Tonyia D.
Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant Klebsiella pneumoniae
title Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant Klebsiella pneumoniae
title_full Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant Klebsiella pneumoniae
title_fullStr Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant Klebsiella pneumoniae
title_full_unstemmed Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant Klebsiella pneumoniae
title_short Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant Klebsiella pneumoniae
title_sort combination of cystatins 9 and c modulates serum biomarkers associated with inflammation and provides prophylactic as well as long-term protection against multidrug-resistant klebsiella pneumoniae
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496045/
https://www.ncbi.nlm.nih.gov/pubmed/30782995
http://dx.doi.org/10.1128/AAC.02519-18
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