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Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant Klebsiella pneumoniae

We have identified recombinant human cystatins 9 (rCST9) and C (rCSTC) as a combination immunotherapeutic treatment against multidrug-resistant (MDR) New Delhi metallo-β-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae. We evaluated the lasting protection of rCST9/rCSTC treatment against MDR NDM-...

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Detalles Bibliográficos
Autores principales:	Holloway, Alex J., Yu, JiehJuen, Arulanandam, Bernard P., Milligan, Gregg N., Eaves-Pyles, Tonyia D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496045/ https://www.ncbi.nlm.nih.gov/pubmed/30782995 http://dx.doi.org/10.1128/AAC.02519-18

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