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Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes
End‐stage liver disease can be the termination of acute or chronic liver diseases, with manifestations of liver failure; transplantation is currently an effective treatment for these. However, transplantation is severely limited due to the serious lack of donors, expense, graft rejection and require...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496737/ https://www.ncbi.nlm.nih.gov/pubmed/25656979 http://dx.doi.org/10.1111/cpr.12165 |
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author | Ye, Jun‐Song Su, Xiao‐San Stoltz, J.‐F. de Isla, N. Zhang, Lei |
author_facet | Ye, Jun‐Song Su, Xiao‐San Stoltz, J.‐F. de Isla, N. Zhang, Lei |
author_sort | Ye, Jun‐Song |
collection | PubMed |
description | End‐stage liver disease can be the termination of acute or chronic liver diseases, with manifestations of liver failure; transplantation is currently an effective treatment for these. However, transplantation is severely limited due to the serious lack of donors, expense, graft rejection and requirement of long‐term immunosuppression. Mesenchymal stem cells (MSCs) have attracted considerable attention as therapeutic tools as they can be obtained with relative ease and expanded in culture, along with features of self‐renewal and multidirectional differentiation. Many scientific groups have sought to use MSCs differentiating into functional hepatocytes to be used in cell transplantation with liver tissue engineering to repair diseased organs. In most of the literature, hepatocyte differentiation refers to use of various additional growth factors and cytokines, such as hepatocyte growth factor (HGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), oncostatin M (OSM) and more, and most are involved in signalling pathway regulation and cell–cell/cell–matrix interactions. Signalling pathways have been shown to play critical roles in embryonic development, tumourigenesis, tumour progression, apoptosis and cell‐fate determination. However, mechanisms of MSCs differentiating into hepatocytes, particularly signalling pathways involved, have not as yet been completely illustrated. In this review, we have focused on progress of signalling pathways associated with mesenchymal stem cells differentiating into hepatocytes along with the stepwise differentiation procedure. |
format | Online Article Text |
id | pubmed-6496737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64967372020-03-13 Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes Ye, Jun‐Song Su, Xiao‐San Stoltz, J.‐F. de Isla, N. Zhang, Lei Cell Prolif Review Articles End‐stage liver disease can be the termination of acute or chronic liver diseases, with manifestations of liver failure; transplantation is currently an effective treatment for these. However, transplantation is severely limited due to the serious lack of donors, expense, graft rejection and requirement of long‐term immunosuppression. Mesenchymal stem cells (MSCs) have attracted considerable attention as therapeutic tools as they can be obtained with relative ease and expanded in culture, along with features of self‐renewal and multidirectional differentiation. Many scientific groups have sought to use MSCs differentiating into functional hepatocytes to be used in cell transplantation with liver tissue engineering to repair diseased organs. In most of the literature, hepatocyte differentiation refers to use of various additional growth factors and cytokines, such as hepatocyte growth factor (HGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), oncostatin M (OSM) and more, and most are involved in signalling pathway regulation and cell–cell/cell–matrix interactions. Signalling pathways have been shown to play critical roles in embryonic development, tumourigenesis, tumour progression, apoptosis and cell‐fate determination. However, mechanisms of MSCs differentiating into hepatocytes, particularly signalling pathways involved, have not as yet been completely illustrated. In this review, we have focused on progress of signalling pathways associated with mesenchymal stem cells differentiating into hepatocytes along with the stepwise differentiation procedure. John Wiley and Sons Inc. 2015-02-06 /pmc/articles/PMC6496737/ /pubmed/25656979 http://dx.doi.org/10.1111/cpr.12165 Text en © 2015 The Authors Cell Proliferation Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Articles Ye, Jun‐Song Su, Xiao‐San Stoltz, J.‐F. de Isla, N. Zhang, Lei Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes |
title | Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes |
title_full | Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes |
title_fullStr | Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes |
title_full_unstemmed | Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes |
title_short | Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes |
title_sort | signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496737/ https://www.ncbi.nlm.nih.gov/pubmed/25656979 http://dx.doi.org/10.1111/cpr.12165 |
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