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Golgi protein 73 and its diagnostic value in liver diseases
Golgi protein 73 (GP73, also referred to as Golph 2) with 400 amino acids is a 73 kDa transmembrane glycoprotein typically found in the cis‐Golg complex. It is primarily expressed in epithelial cells, which has been found upregulated in hepatocytes in patients suffering from both viral and non‐viral...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496820/ https://www.ncbi.nlm.nih.gov/pubmed/30341783 http://dx.doi.org/10.1111/cpr.12538 |
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author | Xia, Yanyan Zhang, Yuanying Shen, Mengjiao Xu, Hongpan Li, Zhiyang He, Nongyue |
author_facet | Xia, Yanyan Zhang, Yuanying Shen, Mengjiao Xu, Hongpan Li, Zhiyang He, Nongyue |
author_sort | Xia, Yanyan |
collection | PubMed |
description | Golgi protein 73 (GP73, also referred to as Golph 2) with 400 amino acids is a 73 kDa transmembrane glycoprotein typically found in the cis‐Golg complex. It is primarily expressed in epithelial cells, which has been found upregulated in hepatocytes in patients suffering from both viral and non‐viral liver diseases. GP73 has drawn increasing attention for its potential application in the diagnosis of liver diseases such as hepatitis, liver cirrhosis and liver cancer. Herein, we reviewed the discovery history of GP73 and summarized studies by many groups around the world, aiming at understanding its structure, expression, function, detection methods and the relationship between GP73 and liver diseases in various settings. |
format | Online Article Text |
id | pubmed-6496820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64968202020-03-13 Golgi protein 73 and its diagnostic value in liver diseases Xia, Yanyan Zhang, Yuanying Shen, Mengjiao Xu, Hongpan Li, Zhiyang He, Nongyue Cell Prolif Review Articles Golgi protein 73 (GP73, also referred to as Golph 2) with 400 amino acids is a 73 kDa transmembrane glycoprotein typically found in the cis‐Golg complex. It is primarily expressed in epithelial cells, which has been found upregulated in hepatocytes in patients suffering from both viral and non‐viral liver diseases. GP73 has drawn increasing attention for its potential application in the diagnosis of liver diseases such as hepatitis, liver cirrhosis and liver cancer. Herein, we reviewed the discovery history of GP73 and summarized studies by many groups around the world, aiming at understanding its structure, expression, function, detection methods and the relationship between GP73 and liver diseases in various settings. John Wiley and Sons Inc. 2018-10-19 /pmc/articles/PMC6496820/ /pubmed/30341783 http://dx.doi.org/10.1111/cpr.12538 Text en © 2018 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Xia, Yanyan Zhang, Yuanying Shen, Mengjiao Xu, Hongpan Li, Zhiyang He, Nongyue Golgi protein 73 and its diagnostic value in liver diseases |
title | Golgi protein 73 and its diagnostic value in liver diseases |
title_full | Golgi protein 73 and its diagnostic value in liver diseases |
title_fullStr | Golgi protein 73 and its diagnostic value in liver diseases |
title_full_unstemmed | Golgi protein 73 and its diagnostic value in liver diseases |
title_short | Golgi protein 73 and its diagnostic value in liver diseases |
title_sort | golgi protein 73 and its diagnostic value in liver diseases |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496820/ https://www.ncbi.nlm.nih.gov/pubmed/30341783 http://dx.doi.org/10.1111/cpr.12538 |
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