Antibody Fab‐Fc properties outperform titer in predictive models of SIV vaccine‐induced protection

Characterizing the antigen‐binding and innate immune‐recruiting properties of the humoral response offers the chance to obtain deeper insights into mechanisms of protection than revealed by measuring only overall antibody titer. Here, a high‐throughput, multiplexed Fab‐Fc Array was employed to profi...

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Detalles Bibliográficos
Autores principales: Pittala, Srivamshi, Bagley, Kenneth, Schwartz, Jennifer A, Brown, Eric P, Weiner, Joshua A, Prado, Ilia J, Zhang, Wenlei, Xu, Rong, Ota‐Setlik, Ayuko, Pal, Ranajit, Shen, Xiaoying, Beck, Charles, Ferrari, Guido, Lewis, George K, LaBranche, Celia C, Montefiori, David C, Tomaras, Georgia D, Alter, Galit, Roederer, Mario, Fouts, Timothy R, Ackerman, Margaret E, Bailey‐Kellogg, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497031/
https://www.ncbi.nlm.nih.gov/pubmed/31048360
http://dx.doi.org/10.15252/msb.20188747

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