Cargando…

Investigating the addition of oral HIV self-tests among populations with high testing coverage – Do they add value? Lessons from a study in Khayelitsha, South Africa

INTRODUCTION: HIV self-testing (HIVST) offers a useful addition to HIV testing services and enables individuals to test privately. Despite recommendations to the contrary, repeat HIV testing is frequent among people already on anti-retroviral treatment (ART) and there are concerns that oral self-tes...

Descripción completa

Detalles Bibliográficos
Autores principales: Moore, Hazel Ann, Metcalf, Carol A., Cassidy, Tali, Hacking, Damian, Shroufi, Amir, Steele, Sarah Jane, Duran, Laura Trivino, Ellman, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497254/
https://www.ncbi.nlm.nih.gov/pubmed/31048859
http://dx.doi.org/10.1371/journal.pone.0215454
_version_ 1783415436301303808
author Moore, Hazel Ann
Metcalf, Carol A.
Cassidy, Tali
Hacking, Damian
Shroufi, Amir
Steele, Sarah Jane
Duran, Laura Trivino
Ellman, Tom
author_facet Moore, Hazel Ann
Metcalf, Carol A.
Cassidy, Tali
Hacking, Damian
Shroufi, Amir
Steele, Sarah Jane
Duran, Laura Trivino
Ellman, Tom
author_sort Moore, Hazel Ann
collection PubMed
description INTRODUCTION: HIV self-testing (HIVST) offers a useful addition to HIV testing services and enables individuals to test privately. Despite recommendations to the contrary, repeat HIV testing is frequent among people already on anti-retroviral treatment (ART) and there are concerns that oral self-testing might lead to false negative results. A study was conducted in Khayelitsha, South Africa, to assess feasibility and uptake of HIVST and linkage-to-care following HIVST. METHODS: Participants were recruited at two health facilities from 1 March 2016 to 31 March 2017. People under 18 years, or with self-reported previously-diagnosed HIV infection, were excluded. Participants received an OraQuick Rapid HIV-1/2 Antibody kit, and reported their HIVST results by pre-paid text message (SMS) or by returning to the facility. Those not reporting within 7 days were contacted by phone. Electronic and paper-based clinical and laboratory records were retrospectively examined for all participants to identify known HIV outcomes, after matching for name, date of birth, and sex. These findings were compared with self-reported HIVST results where available. RESULTS: Of 639 participants, 401 (62.8%) self-reported a negative HIVST result, 27 (4.2%) a positive result, and 211 (33.0%) did not report. The record search identified that of the 401 participants self-reporting a negative HIVST result, 19 (4.7%) were already known to be HIV positive; of the 27 self-reporting positive, 12 (44%) were known HIV positive. Overall, records showed 57/639 (8.9%) were HIV positive of whom 39/57 (68.4%) had previously-diagnosed infection and 18/57 (31.6%) newly-diagnosed infection. Of the 428 participants who self-reported a result, 366 (85.5%) reported by SMS. CONCLUSIONS: HIVST can improve HIV testing uptake and linkage to care. SMS is acceptable for reporting HIVST results but negative self-reports by participants may be unreliable. Use of HIVST by individuals on ART is frequent despite recommendations to the contrary and its implications need further consideration.
format Online
Article
Text
id pubmed-6497254
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-64972542019-05-17 Investigating the addition of oral HIV self-tests among populations with high testing coverage – Do they add value? Lessons from a study in Khayelitsha, South Africa Moore, Hazel Ann Metcalf, Carol A. Cassidy, Tali Hacking, Damian Shroufi, Amir Steele, Sarah Jane Duran, Laura Trivino Ellman, Tom PLoS One Research Article INTRODUCTION: HIV self-testing (HIVST) offers a useful addition to HIV testing services and enables individuals to test privately. Despite recommendations to the contrary, repeat HIV testing is frequent among people already on anti-retroviral treatment (ART) and there are concerns that oral self-testing might lead to false negative results. A study was conducted in Khayelitsha, South Africa, to assess feasibility and uptake of HIVST and linkage-to-care following HIVST. METHODS: Participants were recruited at two health facilities from 1 March 2016 to 31 March 2017. People under 18 years, or with self-reported previously-diagnosed HIV infection, were excluded. Participants received an OraQuick Rapid HIV-1/2 Antibody kit, and reported their HIVST results by pre-paid text message (SMS) or by returning to the facility. Those not reporting within 7 days were contacted by phone. Electronic and paper-based clinical and laboratory records were retrospectively examined for all participants to identify known HIV outcomes, after matching for name, date of birth, and sex. These findings were compared with self-reported HIVST results where available. RESULTS: Of 639 participants, 401 (62.8%) self-reported a negative HIVST result, 27 (4.2%) a positive result, and 211 (33.0%) did not report. The record search identified that of the 401 participants self-reporting a negative HIVST result, 19 (4.7%) were already known to be HIV positive; of the 27 self-reporting positive, 12 (44%) were known HIV positive. Overall, records showed 57/639 (8.9%) were HIV positive of whom 39/57 (68.4%) had previously-diagnosed infection and 18/57 (31.6%) newly-diagnosed infection. Of the 428 participants who self-reported a result, 366 (85.5%) reported by SMS. CONCLUSIONS: HIVST can improve HIV testing uptake and linkage to care. SMS is acceptable for reporting HIVST results but negative self-reports by participants may be unreliable. Use of HIVST by individuals on ART is frequent despite recommendations to the contrary and its implications need further consideration. Public Library of Science 2019-05-02 /pmc/articles/PMC6497254/ /pubmed/31048859 http://dx.doi.org/10.1371/journal.pone.0215454 Text en © 2019 Moore et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Moore, Hazel Ann
Metcalf, Carol A.
Cassidy, Tali
Hacking, Damian
Shroufi, Amir
Steele, Sarah Jane
Duran, Laura Trivino
Ellman, Tom
Investigating the addition of oral HIV self-tests among populations with high testing coverage – Do they add value? Lessons from a study in Khayelitsha, South Africa
title Investigating the addition of oral HIV self-tests among populations with high testing coverage – Do they add value? Lessons from a study in Khayelitsha, South Africa
title_full Investigating the addition of oral HIV self-tests among populations with high testing coverage – Do they add value? Lessons from a study in Khayelitsha, South Africa
title_fullStr Investigating the addition of oral HIV self-tests among populations with high testing coverage – Do they add value? Lessons from a study in Khayelitsha, South Africa
title_full_unstemmed Investigating the addition of oral HIV self-tests among populations with high testing coverage – Do they add value? Lessons from a study in Khayelitsha, South Africa
title_short Investigating the addition of oral HIV self-tests among populations with high testing coverage – Do they add value? Lessons from a study in Khayelitsha, South Africa
title_sort investigating the addition of oral hiv self-tests among populations with high testing coverage – do they add value? lessons from a study in khayelitsha, south africa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497254/
https://www.ncbi.nlm.nih.gov/pubmed/31048859
http://dx.doi.org/10.1371/journal.pone.0215454
work_keys_str_mv AT moorehazelann investigatingtheadditionoforalhivselftestsamongpopulationswithhightestingcoveragedotheyaddvaluelessonsfromastudyinkhayelitshasouthafrica
AT metcalfcarola investigatingtheadditionoforalhivselftestsamongpopulationswithhightestingcoveragedotheyaddvaluelessonsfromastudyinkhayelitshasouthafrica
AT cassidytali investigatingtheadditionoforalhivselftestsamongpopulationswithhightestingcoveragedotheyaddvaluelessonsfromastudyinkhayelitshasouthafrica
AT hackingdamian investigatingtheadditionoforalhivselftestsamongpopulationswithhightestingcoveragedotheyaddvaluelessonsfromastudyinkhayelitshasouthafrica
AT shroufiamir investigatingtheadditionoforalhivselftestsamongpopulationswithhightestingcoveragedotheyaddvaluelessonsfromastudyinkhayelitshasouthafrica
AT steelesarahjane investigatingtheadditionoforalhivselftestsamongpopulationswithhightestingcoveragedotheyaddvaluelessonsfromastudyinkhayelitshasouthafrica
AT duranlauratrivino investigatingtheadditionoforalhivselftestsamongpopulationswithhightestingcoveragedotheyaddvaluelessonsfromastudyinkhayelitshasouthafrica
AT ellmantom investigatingtheadditionoforalhivselftestsamongpopulationswithhightestingcoveragedotheyaddvaluelessonsfromastudyinkhayelitshasouthafrica