An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals

FINDINGS: Here, we demonstrate that OP2113 (5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione, CAS 532-11-6), synthesized and used as a drug since 1696, does not act as an unspecific antioxidant molecule (i.e., as a radical scavenger) but unexpectedly decreases mitochondrial reactive oxygen species (ROS/...

Descripción completa

Detalles Bibliográficos
Autores principales: Detaille, Dominique, Pasdois, Philippe, Sémont, Audrey, Dos Santos, Pierre, Diolez, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497312/
https://www.ncbi.nlm.nih.gov/pubmed/31048932
http://dx.doi.org/10.1371/journal.pone.0216385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497312/
https://www.ncbi.nlm.nih.gov/pubmed/31048932
http://dx.doi.org/10.1371/journal.pone.0216385

Ejemplares similares