Natural gypenosides: targeting cancer through different molecular pathways

The second foremost cause of mortality around the word is cancer. Conventional therapies, such as radiation, surgery, and chemotherapy have limited accessibility owing to secondary resistance. Therefore, convenient, safe, and nonresistant drugs are urgently needed. Plant-derived natural products hav...

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Autores principales: Ahmad, Bashir, Khan, Suliman, Nabi, Ghulam, Gamallat, Yaser, Su, Pengyu, Jamalat, Yazeed, Duan, Pengfei, Yao, Lunguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497488/
https://www.ncbi.nlm.nih.gov/pubmed/31114315
http://dx.doi.org/10.2147/CMAR.S185232
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author Ahmad, Bashir
Khan, Suliman
Nabi, Ghulam
Gamallat, Yaser
Su, Pengyu
Jamalat, Yazeed
Duan, Pengfei
Yao, Lunguang
author_facet Ahmad, Bashir
Khan, Suliman
Nabi, Ghulam
Gamallat, Yaser
Su, Pengyu
Jamalat, Yazeed
Duan, Pengfei
Yao, Lunguang
author_sort Ahmad, Bashir
collection PubMed
description The second foremost cause of mortality around the word is cancer. Conventional therapies, such as radiation, surgery, and chemotherapy have limited accessibility owing to secondary resistance. Therefore, convenient, safe, and nonresistant drugs are urgently needed. Plant-derived natural products have attracted considerable interest owing to their high efficacy, low toxicity, and convenience. Gypenosides (Gyp) inhibit invasion, migration, metastasis, and proliferation and induce apoptosis in different cancers, including oral, lung, colorectal, hepatocellular, and leukemic cancers through different molecular pathways. This review summarizes Gyp studies on cancer to serve as a reference for further research and clinical trials.
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spelling pubmed-64974882019-05-21 Natural gypenosides: targeting cancer through different molecular pathways Ahmad, Bashir Khan, Suliman Nabi, Ghulam Gamallat, Yaser Su, Pengyu Jamalat, Yazeed Duan, Pengfei Yao, Lunguang Cancer Manag Res Review The second foremost cause of mortality around the word is cancer. Conventional therapies, such as radiation, surgery, and chemotherapy have limited accessibility owing to secondary resistance. Therefore, convenient, safe, and nonresistant drugs are urgently needed. Plant-derived natural products have attracted considerable interest owing to their high efficacy, low toxicity, and convenience. Gypenosides (Gyp) inhibit invasion, migration, metastasis, and proliferation and induce apoptosis in different cancers, including oral, lung, colorectal, hepatocellular, and leukemic cancers through different molecular pathways. This review summarizes Gyp studies on cancer to serve as a reference for further research and clinical trials. Dove 2019-03-27 /pmc/articles/PMC6497488/ /pubmed/31114315 http://dx.doi.org/10.2147/CMAR.S185232 Text en © 2019 Ahmad et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Ahmad, Bashir
Khan, Suliman
Nabi, Ghulam
Gamallat, Yaser
Su, Pengyu
Jamalat, Yazeed
Duan, Pengfei
Yao, Lunguang
Natural gypenosides: targeting cancer through different molecular pathways
title Natural gypenosides: targeting cancer through different molecular pathways
title_full Natural gypenosides: targeting cancer through different molecular pathways
title_fullStr Natural gypenosides: targeting cancer through different molecular pathways
title_full_unstemmed Natural gypenosides: targeting cancer through different molecular pathways
title_short Natural gypenosides: targeting cancer through different molecular pathways
title_sort natural gypenosides: targeting cancer through different molecular pathways
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497488/
https://www.ncbi.nlm.nih.gov/pubmed/31114315
http://dx.doi.org/10.2147/CMAR.S185232
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