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Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model

While the number of patients supported with temporary cardiac assist is growing, the existing devices are limited by a multitude of complications, mostly related to contact with the blood. The CorInnova epicardial compressive heart assist device was tested in six sheep using an acute heart failure m...

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Detalles Bibliográficos
Autores principales: Hord, Erica C., Bolch, Christina M., Tuzun, Egemen, Cohn, William E., Leschinsky, Boris, Criscione, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497617/
https://www.ncbi.nlm.nih.gov/pubmed/30604307
http://dx.doi.org/10.1007/s12265-018-9854-5
Descripción
Sumario:While the number of patients supported with temporary cardiac assist is growing, the existing devices are limited by a multitude of complications, mostly related to contact with the blood. The CorInnova epicardial compressive heart assist device was tested in six sheep using an acute heart failure model. High esmolol dose, targeting a 50% reduction in CO from healthy baseline, resulted in a failure state with mean CO 1.9 L/min. Heart assist with the device during failure state resulted in an average absolute increase in CO of 1.0 L/min, along with a decline in ventricular work to 67.5% of the total LV SW. Combined with repeated success of minimally invasive device implant, the resulting increases in cardiac hemodynamics achieved while still unloading the heart demonstrate the potential of the CorInnova device for temporary heart assist. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12265-018-9854-5) contains supplementary material, which is available to authorized users.