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Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model

While the number of patients supported with temporary cardiac assist is growing, the existing devices are limited by a multitude of complications, mostly related to contact with the blood. The CorInnova epicardial compressive heart assist device was tested in six sheep using an acute heart failure m...

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Autores principales: Hord, Erica C., Bolch, Christina M., Tuzun, Egemen, Cohn, William E., Leschinsky, Boris, Criscione, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497617/
https://www.ncbi.nlm.nih.gov/pubmed/30604307
http://dx.doi.org/10.1007/s12265-018-9854-5
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author Hord, Erica C.
Bolch, Christina M.
Tuzun, Egemen
Cohn, William E.
Leschinsky, Boris
Criscione, John C.
author_facet Hord, Erica C.
Bolch, Christina M.
Tuzun, Egemen
Cohn, William E.
Leschinsky, Boris
Criscione, John C.
author_sort Hord, Erica C.
collection PubMed
description While the number of patients supported with temporary cardiac assist is growing, the existing devices are limited by a multitude of complications, mostly related to contact with the blood. The CorInnova epicardial compressive heart assist device was tested in six sheep using an acute heart failure model. High esmolol dose, targeting a 50% reduction in CO from healthy baseline, resulted in a failure state with mean CO 1.9 L/min. Heart assist with the device during failure state resulted in an average absolute increase in CO of 1.0 L/min, along with a decline in ventricular work to 67.5% of the total LV SW. Combined with repeated success of minimally invasive device implant, the resulting increases in cardiac hemodynamics achieved while still unloading the heart demonstrate the potential of the CorInnova device for temporary heart assist. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12265-018-9854-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-64976172019-05-17 Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model Hord, Erica C. Bolch, Christina M. Tuzun, Egemen Cohn, William E. Leschinsky, Boris Criscione, John C. J Cardiovasc Transl Res Original Article While the number of patients supported with temporary cardiac assist is growing, the existing devices are limited by a multitude of complications, mostly related to contact with the blood. The CorInnova epicardial compressive heart assist device was tested in six sheep using an acute heart failure model. High esmolol dose, targeting a 50% reduction in CO from healthy baseline, resulted in a failure state with mean CO 1.9 L/min. Heart assist with the device during failure state resulted in an average absolute increase in CO of 1.0 L/min, along with a decline in ventricular work to 67.5% of the total LV SW. Combined with repeated success of minimally invasive device implant, the resulting increases in cardiac hemodynamics achieved while still unloading the heart demonstrate the potential of the CorInnova device for temporary heart assist. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12265-018-9854-5) contains supplementary material, which is available to authorized users. Springer US 2019-01-02 2019 /pmc/articles/PMC6497617/ /pubmed/30604307 http://dx.doi.org/10.1007/s12265-018-9854-5 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Hord, Erica C.
Bolch, Christina M.
Tuzun, Egemen
Cohn, William E.
Leschinsky, Boris
Criscione, John C.
Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model
title Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model
title_full Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model
title_fullStr Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model
title_full_unstemmed Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model
title_short Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model
title_sort evaluation of the corinnova heart assist device in an acute heart failure model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497617/
https://www.ncbi.nlm.nih.gov/pubmed/30604307
http://dx.doi.org/10.1007/s12265-018-9854-5
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