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CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons
Patient-specific induced pluripotent stem cells (iPSCs) are a powerful tool to investigate the molecular mechanisms underlying Parkinson’s disease (PD), and might provide novel platforms for systematic drug screening. Several strategies have been developed to generate iPSC-derived tyrosine hydroxyla...
Autores principales: | Calatayud, Carles, Carola, Giulia, Fernández-Carasa, Irene, Valtorta, Marco, Jiménez-Delgado, Senda, Díaz, Mònica, Soriano-Fradera, Jordi, Cappelletti, Graziella, García-Sancho, Javier, Raya, Ángel, Consiglio, Antonella |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497635/ https://www.ncbi.nlm.nih.gov/pubmed/31048719 http://dx.doi.org/10.1038/s41598-019-43080-2 |
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