The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM(2.5)-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings

Fine particulate matter 2.5 (PM(2.5)) induces free radicals and oxidative stress in animals, leading to a range of illnesses. In this study, Ganoderma Microsporum immunomodulatory (GMI) proteins were administered to alleviate PM(2.5)-induced inflammatory responses in mother rats, and PM(2.5)-induced...

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Autores principales: Tseng, Chia-Yi, Yu, Jia-Yu, Chuang, Yu-Chen, Lin, Chia-Ying, Wu, Chun-Hao, Liao, Chia-Wei, Yang, Fu-Hua, Chao, Ming-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497649/
https://www.ncbi.nlm.nih.gov/pubmed/31048730
http://dx.doi.org/10.1038/s41598-019-38810-5
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author Tseng, Chia-Yi
Yu, Jia-Yu
Chuang, Yu-Chen
Lin, Chia-Ying
Wu, Chun-Hao
Liao, Chia-Wei
Yang, Fu-Hua
Chao, Ming-Wei
author_facet Tseng, Chia-Yi
Yu, Jia-Yu
Chuang, Yu-Chen
Lin, Chia-Ying
Wu, Chun-Hao
Liao, Chia-Wei
Yang, Fu-Hua
Chao, Ming-Wei
author_sort Tseng, Chia-Yi
collection PubMed
description Fine particulate matter 2.5 (PM(2.5)) induces free radicals and oxidative stress in animals, leading to a range of illnesses. In this study, Ganoderma Microsporum immunomodulatory (GMI) proteins were administered to alleviate PM(2.5)-induced inflammatory responses in mother rats, and PM(2.5)-induced inflammatory responses and neurological damage in their offspring. The results suggested that GMI administration decreased the risk of neurological disorders in mother rats and their offspring by reducing the white blood cell count, lessening inflammatory responses and PM(2.5)-induced memory impairment, and preventing dendritic branches in the hippocampi from declining and microRNAs from PM(2.5)-induced modulation.
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spelling pubmed-64976492019-05-17 The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM(2.5)-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings Tseng, Chia-Yi Yu, Jia-Yu Chuang, Yu-Chen Lin, Chia-Ying Wu, Chun-Hao Liao, Chia-Wei Yang, Fu-Hua Chao, Ming-Wei Sci Rep Article Fine particulate matter 2.5 (PM(2.5)) induces free radicals and oxidative stress in animals, leading to a range of illnesses. In this study, Ganoderma Microsporum immunomodulatory (GMI) proteins were administered to alleviate PM(2.5)-induced inflammatory responses in mother rats, and PM(2.5)-induced inflammatory responses and neurological damage in their offspring. The results suggested that GMI administration decreased the risk of neurological disorders in mother rats and their offspring by reducing the white blood cell count, lessening inflammatory responses and PM(2.5)-induced memory impairment, and preventing dendritic branches in the hippocampi from declining and microRNAs from PM(2.5)-induced modulation. Nature Publishing Group UK 2019-05-02 /pmc/articles/PMC6497649/ /pubmed/31048730 http://dx.doi.org/10.1038/s41598-019-38810-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tseng, Chia-Yi
Yu, Jia-Yu
Chuang, Yu-Chen
Lin, Chia-Ying
Wu, Chun-Hao
Liao, Chia-Wei
Yang, Fu-Hua
Chao, Ming-Wei
The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM(2.5)-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings
title The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM(2.5)-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings
title_full The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM(2.5)-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings
title_fullStr The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM(2.5)-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings
title_full_unstemmed The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM(2.5)-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings
title_short The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM(2.5)-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings
title_sort effect of ganoderma microsporum immunomodulatory proteins on alleviating pm(2.5)-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497649/
https://www.ncbi.nlm.nih.gov/pubmed/31048730
http://dx.doi.org/10.1038/s41598-019-38810-5
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