MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAF(V600E) amplification whereas KRAS(G13D) amplification promotes EMT-chemoresistance

Acquired resistance to MEK1/2 inhibitors (MEKi) arises through amplification of BRAF(V600E) or KRAS(G13D) to reinstate ERK1/2 signalling. Here we show that BRAF(V600E) amplification and MEKi resistance are reversible following drug withdrawal. Cells with BRAF(V600E) amplification are addicted to MEK...

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Detalles Bibliográficos
Autores principales: Sale, Matthew J., Balmanno, Kathryn, Saxena, Jayeta, Ozono, Eiko, Wojdyla, Katarzyna, McIntyre, Rebecca E., Gilley, Rebecca, Woroniuk, Anna, Howarth, Karen D., Hughes, Gareth, Dry, Jonathan R., Arends, Mark J., Caro, Pilar, Oxley, David, Ashton, Susan, Adams, David J., Saez-Rodriguez, Julio, Smith, Paul D., Cook, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497655/
https://www.ncbi.nlm.nih.gov/pubmed/31048689
http://dx.doi.org/10.1038/s41467-019-09438-w

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