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Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy

Reality monitoring is defined as the ability to distinguish internally self-generated information from externally-derived information. The medial prefrontal cortex (mPFC) is a key brain region subserving reality monitoring and has been shown to be activated specifically during the retrieval of self-...

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Autores principales: Subramaniam, Karuna, Hinkley, Leighton B. N., Mizuiri, Danielle, Kothare, Hardik, Cai, Chang, Garrett, Coleman, Findlay, Anne, Houde, John F., Nagarajan, Srikantan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497659/
https://www.ncbi.nlm.nih.gov/pubmed/31048735
http://dx.doi.org/10.1038/s41598-019-43291-7
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author Subramaniam, Karuna
Hinkley, Leighton B. N.
Mizuiri, Danielle
Kothare, Hardik
Cai, Chang
Garrett, Coleman
Findlay, Anne
Houde, John F.
Nagarajan, Srikantan S.
author_facet Subramaniam, Karuna
Hinkley, Leighton B. N.
Mizuiri, Danielle
Kothare, Hardik
Cai, Chang
Garrett, Coleman
Findlay, Anne
Houde, John F.
Nagarajan, Srikantan S.
author_sort Subramaniam, Karuna
collection PubMed
description Reality monitoring is defined as the ability to distinguish internally self-generated information from externally-derived information. The medial prefrontal cortex (mPFC) is a key brain region subserving reality monitoring and has been shown to be activated specifically during the retrieval of self-generated information. However, it is unclear if mPFC is activated during the encoding of self-generated information into memory. If so, it is important to understand whether successful retrieval of self-generated information critically depends on enhanced neural activity within mPFC during initial encoding of this self-generated information. We used magnetoencephalographic imaging (MEGI) to determine the timing and location of cortical activity during a reality-monitoring task involving self generated contextual source memory encoding and retrieval. We found both during encoding and retrieval of self-generated information, when compared to externally-derived information, mPFC showed significant task induced oscillatory power modulation in the beta-band. During initial encoding of self-generated information, greater mPFC beta-band power reductions occurred within a time window of −700 ms to −500 ms prior to vocalization. This increased activity in mPFC was not observed during encoding of externally-derived information. Additionally, increased mPFC activity during encoding of self-generated information predicted subsequent retrieval accuracy of this self-generated information. Beta-band activity in mPFC was also observed during the initial retrieval of self-generated information within a time window of 300 to 500 ms following stimulus onset and correlated with accurate retrieval performance of self-generated information. Together, these results further highlight the importance of mPFC in mediating the initial generation and awareness of participants’ internal thoughts.
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spelling pubmed-64976592019-05-17 Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy Subramaniam, Karuna Hinkley, Leighton B. N. Mizuiri, Danielle Kothare, Hardik Cai, Chang Garrett, Coleman Findlay, Anne Houde, John F. Nagarajan, Srikantan S. Sci Rep Article Reality monitoring is defined as the ability to distinguish internally self-generated information from externally-derived information. The medial prefrontal cortex (mPFC) is a key brain region subserving reality monitoring and has been shown to be activated specifically during the retrieval of self-generated information. However, it is unclear if mPFC is activated during the encoding of self-generated information into memory. If so, it is important to understand whether successful retrieval of self-generated information critically depends on enhanced neural activity within mPFC during initial encoding of this self-generated information. We used magnetoencephalographic imaging (MEGI) to determine the timing and location of cortical activity during a reality-monitoring task involving self generated contextual source memory encoding and retrieval. We found both during encoding and retrieval of self-generated information, when compared to externally-derived information, mPFC showed significant task induced oscillatory power modulation in the beta-band. During initial encoding of self-generated information, greater mPFC beta-band power reductions occurred within a time window of −700 ms to −500 ms prior to vocalization. This increased activity in mPFC was not observed during encoding of externally-derived information. Additionally, increased mPFC activity during encoding of self-generated information predicted subsequent retrieval accuracy of this self-generated information. Beta-band activity in mPFC was also observed during the initial retrieval of self-generated information within a time window of 300 to 500 ms following stimulus onset and correlated with accurate retrieval performance of self-generated information. Together, these results further highlight the importance of mPFC in mediating the initial generation and awareness of participants’ internal thoughts. Nature Publishing Group UK 2019-05-02 /pmc/articles/PMC6497659/ /pubmed/31048735 http://dx.doi.org/10.1038/s41598-019-43291-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Subramaniam, Karuna
Hinkley, Leighton B. N.
Mizuiri, Danielle
Kothare, Hardik
Cai, Chang
Garrett, Coleman
Findlay, Anne
Houde, John F.
Nagarajan, Srikantan S.
Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy
title Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy
title_full Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy
title_fullStr Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy
title_full_unstemmed Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy
title_short Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy
title_sort beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497659/
https://www.ncbi.nlm.nih.gov/pubmed/31048735
http://dx.doi.org/10.1038/s41598-019-43291-7
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