CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule

CD90 is a membrane GPI-anchored protein with one Ig V-type superfamily domain that was initially described in mouse T cells. Besides the specific expression pattern and functions of CD90 that were described in normal tissues, i.e., neurons, fibroblasts and T cells, increasing evidences are currently...

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Autores principales: Sauzay, Chloé, Voutetakis, Konstantinos, Chatziioannou, Aristotelis, Chevet, Eric, Avril, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497726/
https://www.ncbi.nlm.nih.gov/pubmed/31080802
http://dx.doi.org/10.3389/fcell.2019.00066
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author Sauzay, Chloé
Voutetakis, Konstantinos
Chatziioannou, Aristotelis
Chevet, Eric
Avril, Tony
author_facet Sauzay, Chloé
Voutetakis, Konstantinos
Chatziioannou, Aristotelis
Chevet, Eric
Avril, Tony
author_sort Sauzay, Chloé
collection PubMed
description CD90 is a membrane GPI-anchored protein with one Ig V-type superfamily domain that was initially described in mouse T cells. Besides the specific expression pattern and functions of CD90 that were described in normal tissues, i.e., neurons, fibroblasts and T cells, increasing evidences are currently highlighting the possible involvement of CD90 in cancer. This review first provides a brief overview on CD90 gene, mRNA and protein features and then describes the established links between CD90 and cancer. Finally, we report newly uncovered functional connections between CD90 and endoplasmic reticulum (ER) stress signaling and discuss their potential impact on cancer development.
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spelling pubmed-64977262019-05-10 CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule Sauzay, Chloé Voutetakis, Konstantinos Chatziioannou, Aristotelis Chevet, Eric Avril, Tony Front Cell Dev Biol Cell and Developmental Biology CD90 is a membrane GPI-anchored protein with one Ig V-type superfamily domain that was initially described in mouse T cells. Besides the specific expression pattern and functions of CD90 that were described in normal tissues, i.e., neurons, fibroblasts and T cells, increasing evidences are currently highlighting the possible involvement of CD90 in cancer. This review first provides a brief overview on CD90 gene, mRNA and protein features and then describes the established links between CD90 and cancer. Finally, we report newly uncovered functional connections between CD90 and endoplasmic reticulum (ER) stress signaling and discuss their potential impact on cancer development. Frontiers Media S.A. 2019-04-26 /pmc/articles/PMC6497726/ /pubmed/31080802 http://dx.doi.org/10.3389/fcell.2019.00066 Text en Copyright © 2019 Sauzay, Voutetakis, Chatziioannou, Chevet and Avril. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Sauzay, Chloé
Voutetakis, Konstantinos
Chatziioannou, Aristotelis
Chevet, Eric
Avril, Tony
CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule
title CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule
title_full CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule
title_fullStr CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule
title_full_unstemmed CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule
title_short CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule
title_sort cd90/thy-1, a cancer-associated cell surface signaling molecule
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497726/
https://www.ncbi.nlm.nih.gov/pubmed/31080802
http://dx.doi.org/10.3389/fcell.2019.00066
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