Stereoselectivity Switch in the Reduction of α-Alkyl-β-Arylenones by Structure-Guided Designed Variants of the Ene Reductase OYE1

Ene reductases from the Old Yellow Enzyme (OYE) family are industrially interesting enzymes for the biocatalytic asymmetric reduction of alkenes. To access both enantiomers of the target reduced products, stereocomplementary pairs of OYE enzymes are necessary, but their natural occurrence is quite l...

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Detalles Bibliográficos
Autores principales: Crotti, Michele, Parmeggiani, Fabio, Ferrandi, Erica Elisa, Gatti, Francesco G., Sacchetti, Alessandro, Riva, Sergio, Brenna, Elisabetta, Monti, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497740/
https://www.ncbi.nlm.nih.gov/pubmed/31080798
http://dx.doi.org/10.3389/fbioe.2019.00089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497740/
https://www.ncbi.nlm.nih.gov/pubmed/31080798
http://dx.doi.org/10.3389/fbioe.2019.00089

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