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Flavin Conjugated Polydopamine Nanoparticles Displaying Light-Driven Monooxygenase Activity

A hybrid of flavin and polydopamine (PDA) has been explored as a photocatalyst, drawing inspiration from natural flavoenzymes. Light-driven monoxygenase activity has been demonstrated through the oxidation of indole under blue light irradiation in ambient conditions, to afford indigo and indirubin d...

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Detalles Bibliográficos
Autores principales: Crocker, Leander, Fruk, Ljiljana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497766/
https://www.ncbi.nlm.nih.gov/pubmed/31080793
http://dx.doi.org/10.3389/fchem.2019.00278
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author Crocker, Leander
Fruk, Ljiljana
author_facet Crocker, Leander
Fruk, Ljiljana
author_sort Crocker, Leander
collection PubMed
description A hybrid of flavin and polydopamine (PDA) has been explored as a photocatalyst, drawing inspiration from natural flavoenzymes. Light-driven monoxygenase activity has been demonstrated through the oxidation of indole under blue light irradiation in ambient conditions, to afford indigo and indirubin dyes. Compared to riboflavin, a flavin-polydopamine hybrid is shown to be more resistant to photobleaching and more selective toward dye production. In addition, it has been demonstrated that it can be recycled from the solution and used for up to four cycles without a marked loss of activity, which is a significant improvement compared to other heterogenous flavin catalysts. The mechanism of action has been explored, indicating that the PDA shell plays an important role in the stabilization of the intermediate flavin-peroxy species, an active component of the catalytic system rather than acting only as a passive nanocarrier of active centers.
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spelling pubmed-64977662019-05-10 Flavin Conjugated Polydopamine Nanoparticles Displaying Light-Driven Monooxygenase Activity Crocker, Leander Fruk, Ljiljana Front Chem Chemistry A hybrid of flavin and polydopamine (PDA) has been explored as a photocatalyst, drawing inspiration from natural flavoenzymes. Light-driven monoxygenase activity has been demonstrated through the oxidation of indole under blue light irradiation in ambient conditions, to afford indigo and indirubin dyes. Compared to riboflavin, a flavin-polydopamine hybrid is shown to be more resistant to photobleaching and more selective toward dye production. In addition, it has been demonstrated that it can be recycled from the solution and used for up to four cycles without a marked loss of activity, which is a significant improvement compared to other heterogenous flavin catalysts. The mechanism of action has been explored, indicating that the PDA shell plays an important role in the stabilization of the intermediate flavin-peroxy species, an active component of the catalytic system rather than acting only as a passive nanocarrier of active centers. Frontiers Media S.A. 2019-04-26 /pmc/articles/PMC6497766/ /pubmed/31080793 http://dx.doi.org/10.3389/fchem.2019.00278 Text en Copyright © 2019 Crocker and Fruk. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Crocker, Leander
Fruk, Ljiljana
Flavin Conjugated Polydopamine Nanoparticles Displaying Light-Driven Monooxygenase Activity
title Flavin Conjugated Polydopamine Nanoparticles Displaying Light-Driven Monooxygenase Activity
title_full Flavin Conjugated Polydopamine Nanoparticles Displaying Light-Driven Monooxygenase Activity
title_fullStr Flavin Conjugated Polydopamine Nanoparticles Displaying Light-Driven Monooxygenase Activity
title_full_unstemmed Flavin Conjugated Polydopamine Nanoparticles Displaying Light-Driven Monooxygenase Activity
title_short Flavin Conjugated Polydopamine Nanoparticles Displaying Light-Driven Monooxygenase Activity
title_sort flavin conjugated polydopamine nanoparticles displaying light-driven monooxygenase activity
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497766/
https://www.ncbi.nlm.nih.gov/pubmed/31080793
http://dx.doi.org/10.3389/fchem.2019.00278
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