Diazepam Accelerates GABA(A)R Synaptic Exchange and Alters Intracellular Trafficking

Despite 50+ years of clinical use as anxiolytics, anti-convulsants, and sedative/hypnotic agents, the mechanisms underlying benzodiazepine (BZD) tolerance are poorly understood. BZDs potentiate the actions of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the adult brain,...

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Detalles Bibliográficos
Autores principales: Lorenz-Guertin, Joshua M., Bambino, Matthew J., Das, Sabyasachi, Weintraub, Susan T., Jacob, Tija C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497791/
https://www.ncbi.nlm.nih.gov/pubmed/31080408
http://dx.doi.org/10.3389/fncel.2019.00163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497791/
https://www.ncbi.nlm.nih.gov/pubmed/31080408
http://dx.doi.org/10.3389/fncel.2019.00163

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