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Genome-Wide Identification of Host Genes Required for Toxicity of Bacterial Cytolethal Distending Toxin in a Yeast Model

BACKGROUND: Aggregatibacter actinomycetemcomitans, a periodontal pathogen, secretes a cytolethal distending toxin (AaCDT) that causes host cell cycle arrest and cell death. Although CDT could be an important virulence factor, it is unclear how it enters the nucleus to exert its cytotoxicity. OBJECTI...

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Detalles Bibliográficos
Autores principales:	Denmongkholchai, Siriyod, Katare, Prashant, Choochuay, Sarocha, Thanyasrisung, Panida, Tsuruda, Keiko, Sugai, Motoyuki, Mongkolsuk, Skorn, Matangkasombut, Oranart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497811/ https://www.ncbi.nlm.nih.gov/pubmed/31080443 http://dx.doi.org/10.3389/fmicb.2019.00890

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