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Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial
Schizophrenia patients have significantly lower life expectancy than the general population. Clozapine is the most effective antipsychotic to reduce the mortality rate in these patients. Here, we report a schizophrenic patient with clozapine‐induced myocarditis and successful retrial. In the first t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498130/ https://www.ncbi.nlm.nih.gov/pubmed/31065477 http://dx.doi.org/10.1002/jgf2.239 |
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author | Otsuka, Yuji Idemoto, Keita Hosoda, Yutaka Imamura, Yukitsugu Aoki, Tsutomu |
author_facet | Otsuka, Yuji Idemoto, Keita Hosoda, Yutaka Imamura, Yukitsugu Aoki, Tsutomu |
author_sort | Otsuka, Yuji |
collection | PubMed |
description | Schizophrenia patients have significantly lower life expectancy than the general population. Clozapine is the most effective antipsychotic to reduce the mortality rate in these patients. Here, we report a schizophrenic patient with clozapine‐induced myocarditis and successful retrial. In the first trial, clozapine was discontinued due to myocarditis. In the second trial, the titration rate was slower, and sodium valproate was not coadministered with clozapine. The patient has not developed myocarditis over 3.5 years of observation. It may be possible to take clozapine for a long time even after clozapine‐induced myocarditis, and thus improve the life expectancy of schizophrenia patients. |
format | Online Article Text |
id | pubmed-6498130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64981302019-05-07 Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial Otsuka, Yuji Idemoto, Keita Hosoda, Yutaka Imamura, Yukitsugu Aoki, Tsutomu J Gen Fam Med Case Reports Schizophrenia patients have significantly lower life expectancy than the general population. Clozapine is the most effective antipsychotic to reduce the mortality rate in these patients. Here, we report a schizophrenic patient with clozapine‐induced myocarditis and successful retrial. In the first trial, clozapine was discontinued due to myocarditis. In the second trial, the titration rate was slower, and sodium valproate was not coadministered with clozapine. The patient has not developed myocarditis over 3.5 years of observation. It may be possible to take clozapine for a long time even after clozapine‐induced myocarditis, and thus improve the life expectancy of schizophrenia patients. John Wiley and Sons Inc. 2019-02-27 /pmc/articles/PMC6498130/ /pubmed/31065477 http://dx.doi.org/10.1002/jgf2.239 Text en © 2019 The Authors. Journal of General and Family Medicine published by John Wiley & Sons Australia, Ltd on behalf of Japan Primary Care Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Reports Otsuka, Yuji Idemoto, Keita Hosoda, Yutaka Imamura, Yukitsugu Aoki, Tsutomu Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial |
title | Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial |
title_full | Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial |
title_fullStr | Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial |
title_full_unstemmed | Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial |
title_short | Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial |
title_sort | clozapine‐induced myocarditis: follow‐up for 3.5 years after successful retrial |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498130/ https://www.ncbi.nlm.nih.gov/pubmed/31065477 http://dx.doi.org/10.1002/jgf2.239 |
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