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Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial

Schizophrenia patients have significantly lower life expectancy than the general population. Clozapine is the most effective antipsychotic to reduce the mortality rate in these patients. Here, we report a schizophrenic patient with clozapine‐induced myocarditis and successful retrial. In the first t...

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Autores principales: Otsuka, Yuji, Idemoto, Keita, Hosoda, Yutaka, Imamura, Yukitsugu, Aoki, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498130/
https://www.ncbi.nlm.nih.gov/pubmed/31065477
http://dx.doi.org/10.1002/jgf2.239
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author Otsuka, Yuji
Idemoto, Keita
Hosoda, Yutaka
Imamura, Yukitsugu
Aoki, Tsutomu
author_facet Otsuka, Yuji
Idemoto, Keita
Hosoda, Yutaka
Imamura, Yukitsugu
Aoki, Tsutomu
author_sort Otsuka, Yuji
collection PubMed
description Schizophrenia patients have significantly lower life expectancy than the general population. Clozapine is the most effective antipsychotic to reduce the mortality rate in these patients. Here, we report a schizophrenic patient with clozapine‐induced myocarditis and successful retrial. In the first trial, clozapine was discontinued due to myocarditis. In the second trial, the titration rate was slower, and sodium valproate was not coadministered with clozapine. The patient has not developed myocarditis over 3.5 years of observation. It may be possible to take clozapine for a long time even after clozapine‐induced myocarditis, and thus improve the life expectancy of schizophrenia patients.
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spelling pubmed-64981302019-05-07 Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial Otsuka, Yuji Idemoto, Keita Hosoda, Yutaka Imamura, Yukitsugu Aoki, Tsutomu J Gen Fam Med Case Reports Schizophrenia patients have significantly lower life expectancy than the general population. Clozapine is the most effective antipsychotic to reduce the mortality rate in these patients. Here, we report a schizophrenic patient with clozapine‐induced myocarditis and successful retrial. In the first trial, clozapine was discontinued due to myocarditis. In the second trial, the titration rate was slower, and sodium valproate was not coadministered with clozapine. The patient has not developed myocarditis over 3.5 years of observation. It may be possible to take clozapine for a long time even after clozapine‐induced myocarditis, and thus improve the life expectancy of schizophrenia patients. John Wiley and Sons Inc. 2019-02-27 /pmc/articles/PMC6498130/ /pubmed/31065477 http://dx.doi.org/10.1002/jgf2.239 Text en © 2019 The Authors. Journal of General and Family Medicine published by John Wiley & Sons Australia, Ltd on behalf of Japan Primary Care Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Otsuka, Yuji
Idemoto, Keita
Hosoda, Yutaka
Imamura, Yukitsugu
Aoki, Tsutomu
Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial
title Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial
title_full Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial
title_fullStr Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial
title_full_unstemmed Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial
title_short Clozapine‐induced myocarditis: Follow‐up for 3.5 years after successful retrial
title_sort clozapine‐induced myocarditis: follow‐up for 3.5 years after successful retrial
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498130/
https://www.ncbi.nlm.nih.gov/pubmed/31065477
http://dx.doi.org/10.1002/jgf2.239
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