The Preparation of Hollow Mesoporous Bioglass Nanoparticles With Excellent Drug Delivery Capacity for Bone Tissue Regeneration

In this work, hollow mesoporous bioglass (HMBG) nanoparticles were prepared in a hexadecyl trimethyl ammonium bromide (CTAB)-cyclonexane-ethanol-water (O/W) emulsion system. The HMBG nanoparticles possessed higher drug storage ability and stable drug release behavior which resulted from HMBG's...

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Detalles Bibliográficos
Autores principales: Wang, Yudong, Pan, Haobo, Chen, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498186/
https://www.ncbi.nlm.nih.gov/pubmed/31106197
http://dx.doi.org/10.3389/fchem.2019.00283
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author Wang, Yudong
Pan, Haobo
Chen, Xiaofeng
author_facet Wang, Yudong
Pan, Haobo
Chen, Xiaofeng
author_sort Wang, Yudong
collection PubMed
description In this work, hollow mesoporous bioglass (HMBG) nanoparticles were prepared in a hexadecyl trimethyl ammonium bromide (CTAB)-cyclonexane-ethanol-water (O/W) emulsion system. The HMBG nanoparticles possessed higher drug storage ability and stable drug release behavior which resulted from HMBG's unique mesoporous structure. The mesoporous structure could be modulated by adjusting the concentration of CTAB. The specific surface area and drug loading efficiency was as high as 749.619 m(2)g(−1) and 55.1%. Besides, in vivo experiments demonstrated that the HMBG nanoparticles could promote the bone tissue regeneration and the drug-loading HMBG nanoparticles possessed better repair capability. The unique structure and properties might make the HMBG nanoparticles good candidates as drug carriers and repair materials for bone tissue regeneration.
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spelling pubmed-64981862019-05-17 The Preparation of Hollow Mesoporous Bioglass Nanoparticles With Excellent Drug Delivery Capacity for Bone Tissue Regeneration Wang, Yudong Pan, Haobo Chen, Xiaofeng Front Chem Chemistry In this work, hollow mesoporous bioglass (HMBG) nanoparticles were prepared in a hexadecyl trimethyl ammonium bromide (CTAB)-cyclonexane-ethanol-water (O/W) emulsion system. The HMBG nanoparticles possessed higher drug storage ability and stable drug release behavior which resulted from HMBG's unique mesoporous structure. The mesoporous structure could be modulated by adjusting the concentration of CTAB. The specific surface area and drug loading efficiency was as high as 749.619 m(2)g(−1) and 55.1%. Besides, in vivo experiments demonstrated that the HMBG nanoparticles could promote the bone tissue regeneration and the drug-loading HMBG nanoparticles possessed better repair capability. The unique structure and properties might make the HMBG nanoparticles good candidates as drug carriers and repair materials for bone tissue regeneration. Frontiers Media S.A. 2019-04-26 /pmc/articles/PMC6498186/ /pubmed/31106197 http://dx.doi.org/10.3389/fchem.2019.00283 Text en Copyright © 2019 Wang, Pan and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Wang, Yudong
Pan, Haobo
Chen, Xiaofeng
The Preparation of Hollow Mesoporous Bioglass Nanoparticles With Excellent Drug Delivery Capacity for Bone Tissue Regeneration
title The Preparation of Hollow Mesoporous Bioglass Nanoparticles With Excellent Drug Delivery Capacity for Bone Tissue Regeneration
title_full The Preparation of Hollow Mesoporous Bioglass Nanoparticles With Excellent Drug Delivery Capacity for Bone Tissue Regeneration
title_fullStr The Preparation of Hollow Mesoporous Bioglass Nanoparticles With Excellent Drug Delivery Capacity for Bone Tissue Regeneration
title_full_unstemmed The Preparation of Hollow Mesoporous Bioglass Nanoparticles With Excellent Drug Delivery Capacity for Bone Tissue Regeneration
title_short The Preparation of Hollow Mesoporous Bioglass Nanoparticles With Excellent Drug Delivery Capacity for Bone Tissue Regeneration
title_sort preparation of hollow mesoporous bioglass nanoparticles with excellent drug delivery capacity for bone tissue regeneration
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498186/
https://www.ncbi.nlm.nih.gov/pubmed/31106197
http://dx.doi.org/10.3389/fchem.2019.00283
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