Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization

BACKGROUND: This study aimed to design a compound with folic acid (FAH(2)) and vanadyl (IV) for use in the treatment of diabetes. MATERIALS AND METHODS: A novel vanadyl (IV) FAH(2) complex was synthesized and characterized [(FA(2−))(VO(2+))]⋅3H(2)O. The speculated structure of this folate complex was determined using physicochemical techniques including microanalytical analysis, conductivity studies, spectroscopic examination, magnetic measurements, thermogravimetric analyses, and morphological X-ray powder diffraction, and scanning and transmission electron microscopies. The anti-diabetic therapeutic potential of the complexes was tested in a 30-day streptozotocin-induced diabetes rat model. RESULTS: The conductivity test of the complex implied electrolyte behavior. The spectroscopic assessments of the isolated dark yellow solid complex revealed that FAH(2) acts as a bidentate ligand. The coordination process with two vanadyl (IV) ions occurred through the deprotonation of both carboxyl groups of FAH(2) in a regular square pyramid arrangement at a 2(FA)(2−): 2(VO)(2+) molar ratio. XRD, SEM, and TEM analyses revealed the complex crystalline nature of the complex. Treating diabetic rats with vanadyl (IV) FAH(2) complex significantly improved many biological parameters relevant to diabetes pathology with minimal toxicity. CONCLUSION: The data generated in this study indicate that the synthesized vanadyl (IV) folate complex acts as a model of anti-diabetic agent.