Cargando…
The effect of acute stress on salivary markers of inflammation: a systematic review protocol
BACKGROUND: There is an increasing interest in the ability to non-invasively assess biological markers of stress. Measures of inflammation following exposure to acute stress have been assessed in saliva, but a systematic review and meta-analysis of the reliability of changes in response to stress ha...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498465/ https://www.ncbi.nlm.nih.gov/pubmed/31046830 http://dx.doi.org/10.1186/s13643-019-1026-4 |
_version_ | 1783415613961535488 |
---|---|
author | Slavish, Danica C. Szabo, Yvette Z. |
author_facet | Slavish, Danica C. Szabo, Yvette Z. |
author_sort | Slavish, Danica C. |
collection | PubMed |
description | BACKGROUND: There is an increasing interest in the ability to non-invasively assess biological markers of stress. Measures of inflammation following exposure to acute stress have been assessed in saliva, but a systematic review and meta-analysis of the reliability of changes in response to stress has not been conducted. The proposed review aims to update and extend a prior review of this literature by performing a systematic review and meta-analysis, conducting moderator analyses, summarizing and reviewing best practices, and providing recommendations for future research. METHODS AND ANALYSIS: The adopted search strategy will involve the electronic databases PubMed, PsycINFO, and Embase. We will include the articles identified by a 2015 narrative review on a similar topic, as well as use reference treeing to identify additional potentially relevant articles. Identified articles will be independently screened by title and abstract. The full text of potentially relevant articles will then be retrieved and read for full inclusion criteria. Data will be extracted, and random-effects meta-analyses will be conducted in R for articles determined to meet all inclusion criteria. The primary outcome will be the magnitude of changes in inflammatory biomarkers following acute stress exposure, as indicated by Cohen’s d. Participant psychosocial or demographic (e.g., age, gender/sex, race/ethnicity, salivary flow rate, oral health status, health status) and methodological (e.g., stressor type, sample timing, assay technique, sample collection method, study quality) moderators of this response also will be examined using meta-regression. DISCUSSION: This systematic review will synthesize the evidence regarding salivary markers of inflammation in response to acute stress. We anticipate variation across studies but hypothesize that salivary markers of inflammation will increase in response to acute stress. The evidence obtained for this study will help guide future research by providing guidelines for the design and measurement of studies assessing salivary inflammation in response to acute stress. Findings will be disseminated with a peer-reviewed manuscript and an international conference presentation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13643-019-1026-4) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6498465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64984652019-05-09 The effect of acute stress on salivary markers of inflammation: a systematic review protocol Slavish, Danica C. Szabo, Yvette Z. Syst Rev Protocol BACKGROUND: There is an increasing interest in the ability to non-invasively assess biological markers of stress. Measures of inflammation following exposure to acute stress have been assessed in saliva, but a systematic review and meta-analysis of the reliability of changes in response to stress has not been conducted. The proposed review aims to update and extend a prior review of this literature by performing a systematic review and meta-analysis, conducting moderator analyses, summarizing and reviewing best practices, and providing recommendations for future research. METHODS AND ANALYSIS: The adopted search strategy will involve the electronic databases PubMed, PsycINFO, and Embase. We will include the articles identified by a 2015 narrative review on a similar topic, as well as use reference treeing to identify additional potentially relevant articles. Identified articles will be independently screened by title and abstract. The full text of potentially relevant articles will then be retrieved and read for full inclusion criteria. Data will be extracted, and random-effects meta-analyses will be conducted in R for articles determined to meet all inclusion criteria. The primary outcome will be the magnitude of changes in inflammatory biomarkers following acute stress exposure, as indicated by Cohen’s d. Participant psychosocial or demographic (e.g., age, gender/sex, race/ethnicity, salivary flow rate, oral health status, health status) and methodological (e.g., stressor type, sample timing, assay technique, sample collection method, study quality) moderators of this response also will be examined using meta-regression. DISCUSSION: This systematic review will synthesize the evidence regarding salivary markers of inflammation in response to acute stress. We anticipate variation across studies but hypothesize that salivary markers of inflammation will increase in response to acute stress. The evidence obtained for this study will help guide future research by providing guidelines for the design and measurement of studies assessing salivary inflammation in response to acute stress. Findings will be disseminated with a peer-reviewed manuscript and an international conference presentation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13643-019-1026-4) contains supplementary material, which is available to authorized users. BioMed Central 2019-05-02 /pmc/articles/PMC6498465/ /pubmed/31046830 http://dx.doi.org/10.1186/s13643-019-1026-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Protocol Slavish, Danica C. Szabo, Yvette Z. The effect of acute stress on salivary markers of inflammation: a systematic review protocol |
title | The effect of acute stress on salivary markers of inflammation: a systematic review protocol |
title_full | The effect of acute stress on salivary markers of inflammation: a systematic review protocol |
title_fullStr | The effect of acute stress on salivary markers of inflammation: a systematic review protocol |
title_full_unstemmed | The effect of acute stress on salivary markers of inflammation: a systematic review protocol |
title_short | The effect of acute stress on salivary markers of inflammation: a systematic review protocol |
title_sort | effect of acute stress on salivary markers of inflammation: a systematic review protocol |
topic | Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498465/ https://www.ncbi.nlm.nih.gov/pubmed/31046830 http://dx.doi.org/10.1186/s13643-019-1026-4 |
work_keys_str_mv | AT slavishdanicac theeffectofacutestressonsalivarymarkersofinflammationasystematicreviewprotocol AT szaboyvettez theeffectofacutestressonsalivarymarkersofinflammationasystematicreviewprotocol AT slavishdanicac effectofacutestressonsalivarymarkersofinflammationasystematicreviewprotocol AT szaboyvettez effectofacutestressonsalivarymarkersofinflammationasystematicreviewprotocol |