Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner

BACKGROUND: Rewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions. However, persistent repression has been difficult to achie...

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Detalles Bibliográficos
Autores principales: O’Geen, Henriette, Bates, Sofie L., Carter, Sakereh S., Nisson, Karly A., Halmai, Julian, Fink, Kyle D., Rhie, Suhn K., Farnham, Peggy J., Segal, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498470/
https://www.ncbi.nlm.nih.gov/pubmed/31053162
http://dx.doi.org/10.1186/s13072-019-0275-8

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