Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury

Mitochondria take part in a network of cellular processes that regulate cell homeostasis. Defects in mitochondrial function are key pathophysiological changes during acute kidney injury (AKI). Mesenchymal stem cells (MSCs) have shown promising regenerative effects in experimental AKI models, but the...

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Detalles Bibliográficos
Autores principales: Zhao, Lingfei, Hu, Chenxia, Zhang, Ping, Jiang, Hua, Chen, Jianghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498508/
https://www.ncbi.nlm.nih.gov/pubmed/31046805
http://dx.doi.org/10.1186/s12967-019-1893-4
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author Zhao, Lingfei
Hu, Chenxia
Zhang, Ping
Jiang, Hua
Chen, Jianghua
author_facet Zhao, Lingfei
Hu, Chenxia
Zhang, Ping
Jiang, Hua
Chen, Jianghua
author_sort Zhao, Lingfei
collection PubMed
description Mitochondria take part in a network of cellular processes that regulate cell homeostasis. Defects in mitochondrial function are key pathophysiological changes during acute kidney injury (AKI). Mesenchymal stem cells (MSCs) have shown promising regenerative effects in experimental AKI models, but the specific mechanism is still unclear. Some studies have demonstrated that MSCs are able to target mitochondrial dysfunction during AKI. In this review, we summarize these articles, providing an integral and updated view of MSC therapy targeting mitochondrial dysfunction during AKI, which is aimed at promoting the therapeutic effect of MSCs in AKI patients.
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spelling pubmed-64985082019-05-09 Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury Zhao, Lingfei Hu, Chenxia Zhang, Ping Jiang, Hua Chen, Jianghua J Transl Med Review Mitochondria take part in a network of cellular processes that regulate cell homeostasis. Defects in mitochondrial function are key pathophysiological changes during acute kidney injury (AKI). Mesenchymal stem cells (MSCs) have shown promising regenerative effects in experimental AKI models, but the specific mechanism is still unclear. Some studies have demonstrated that MSCs are able to target mitochondrial dysfunction during AKI. In this review, we summarize these articles, providing an integral and updated view of MSC therapy targeting mitochondrial dysfunction during AKI, which is aimed at promoting the therapeutic effect of MSCs in AKI patients. BioMed Central 2019-05-02 /pmc/articles/PMC6498508/ /pubmed/31046805 http://dx.doi.org/10.1186/s12967-019-1893-4 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhao, Lingfei
Hu, Chenxia
Zhang, Ping
Jiang, Hua
Chen, Jianghua
Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury
title Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury
title_full Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury
title_fullStr Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury
title_full_unstemmed Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury
title_short Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury
title_sort mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498508/
https://www.ncbi.nlm.nih.gov/pubmed/31046805
http://dx.doi.org/10.1186/s12967-019-1893-4
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AT jianghua mesenchymalstemcelltherapytargetingmitochondrialdysfunctioninacutekidneyinjury
AT chenjianghua mesenchymalstemcelltherapytargetingmitochondrialdysfunctioninacutekidneyinjury

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