Does anterior chamber-associated immune deviation (ACAID) play a role in posterior lamellar keratoplasty? Case report of a splenectomized patient

BACKGROUND: It has been shown experimentally in rodents that removal of the spleen leads to increased rejection of corneal allografts after corneal transplantation (keratoplasty). CASE PRESENTATION: Here, we report a unique case of a splenectomized patient with corneal endothelial dystrophy who unde...

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Detalles Bibliográficos
Autores principales: Hos, Deniz, Schaub, Friederike, Cursiefen, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498571/
https://www.ncbi.nlm.nih.gov/pubmed/31046736
http://dx.doi.org/10.1186/s12886-019-1114-1
Descripción
Sumario:BACKGROUND: It has been shown experimentally in rodents that removal of the spleen leads to increased rejection of corneal allografts after corneal transplantation (keratoplasty). CASE PRESENTATION: Here, we report a unique case of a splenectomized patient with corneal endothelial dystrophy who underwent posterior lamellar keratoplasty. During follow-up of 4 years, we did not detect any signs of corneal allograft rejection. CONCLUSIONS: Our report indicates that an intact spleen is not necessary for allograft acceptance after posterior lamellar keratoplasty. To the best of our knowledge, this is the first report of a splenectomized patient receiving a (lamellar) corneal transplant.

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