Does anterior chamber-associated immune deviation (ACAID) play a role in posterior lamellar keratoplasty? Case report of a splenectomized patient

BACKGROUND: It has been shown experimentally in rodents that removal of the spleen leads to increased rejection of corneal allografts after corneal transplantation (keratoplasty). CASE PRESENTATION: Here, we report a unique case of a splenectomized patient with corneal endothelial dystrophy who unde...

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Autores principales: Hos, Deniz, Schaub, Friederike, Cursiefen, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498571/
https://www.ncbi.nlm.nih.gov/pubmed/31046736
http://dx.doi.org/10.1186/s12886-019-1114-1
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author Hos, Deniz
Schaub, Friederike
Cursiefen, Claus
author_facet Hos, Deniz
Schaub, Friederike
Cursiefen, Claus
author_sort Hos, Deniz
collection PubMed
description BACKGROUND: It has been shown experimentally in rodents that removal of the spleen leads to increased rejection of corneal allografts after corneal transplantation (keratoplasty). CASE PRESENTATION: Here, we report a unique case of a splenectomized patient with corneal endothelial dystrophy who underwent posterior lamellar keratoplasty. During follow-up of 4 years, we did not detect any signs of corneal allograft rejection. CONCLUSIONS: Our report indicates that an intact spleen is not necessary for allograft acceptance after posterior lamellar keratoplasty. To the best of our knowledge, this is the first report of a splenectomized patient receiving a (lamellar) corneal transplant.
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spelling pubmed-64985712019-05-09 Does anterior chamber-associated immune deviation (ACAID) play a role in posterior lamellar keratoplasty? Case report of a splenectomized patient Hos, Deniz Schaub, Friederike Cursiefen, Claus BMC Ophthalmol Case Report BACKGROUND: It has been shown experimentally in rodents that removal of the spleen leads to increased rejection of corneal allografts after corneal transplantation (keratoplasty). CASE PRESENTATION: Here, we report a unique case of a splenectomized patient with corneal endothelial dystrophy who underwent posterior lamellar keratoplasty. During follow-up of 4 years, we did not detect any signs of corneal allograft rejection. CONCLUSIONS: Our report indicates that an intact spleen is not necessary for allograft acceptance after posterior lamellar keratoplasty. To the best of our knowledge, this is the first report of a splenectomized patient receiving a (lamellar) corneal transplant. BioMed Central 2019-05-02 /pmc/articles/PMC6498571/ /pubmed/31046736 http://dx.doi.org/10.1186/s12886-019-1114-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Hos, Deniz
Schaub, Friederike
Cursiefen, Claus
Does anterior chamber-associated immune deviation (ACAID) play a role in posterior lamellar keratoplasty? Case report of a splenectomized patient
title Does anterior chamber-associated immune deviation (ACAID) play a role in posterior lamellar keratoplasty? Case report of a splenectomized patient
title_full Does anterior chamber-associated immune deviation (ACAID) play a role in posterior lamellar keratoplasty? Case report of a splenectomized patient
title_fullStr Does anterior chamber-associated immune deviation (ACAID) play a role in posterior lamellar keratoplasty? Case report of a splenectomized patient
title_full_unstemmed Does anterior chamber-associated immune deviation (ACAID) play a role in posterior lamellar keratoplasty? Case report of a splenectomized patient
title_short Does anterior chamber-associated immune deviation (ACAID) play a role in posterior lamellar keratoplasty? Case report of a splenectomized patient
title_sort does anterior chamber-associated immune deviation (acaid) play a role in posterior lamellar keratoplasty? case report of a splenectomized patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498571/
https://www.ncbi.nlm.nih.gov/pubmed/31046736
http://dx.doi.org/10.1186/s12886-019-1114-1
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