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Response to Imatinib therapy is inferior for e13a2 BCR-ABL1 transcript type in comparison to e14a2 transcript type in chronic myeloid leukaemia

BACKGROUND: The BCR-ABL1 fusion gene underlying the pathogenesis of CML can arise from a variety of breakpoints. The e13a2 and e14a2 transcripts formed by breakpoints occurring around exon 13 and exon 14 of the BCR gene respectively are the most common. METHODS: We undertook a retrospective audit us...

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Detalles Bibliográficos
Autores principales:	Greenfield, Graeme, McMullan, Ross, Robson, Nuala, McGimpsey, Julie, Catherwood, Mark, McMullin, Mary Frances
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498698/ https://www.ncbi.nlm.nih.gov/pubmed/31073408 http://dx.doi.org/10.1186/s12878-019-0139-2

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