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Canine non‐epitheliotropic CD4‐positive cutaneous T‐cell lymphoma: a case report

A 5‐year‐old, spayed female French Bulldog presented with multiple papules on the skin of the scapular area. Histopathological examination of punch biopsy samples revealed dense infiltration of small lymphoid cells in the superficial dermis and in areas surrounding hair follicles. Immunohistochemica...

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Autores principales: Kondo, Hitoshi, Kagawa, Yumiko, Shirota, Kinji, Moore, Peter F., Nagata, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498901/
https://www.ncbi.nlm.nih.gov/pubmed/30548472
http://dx.doi.org/10.1002/vms3.137
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author Kondo, Hitoshi
Kagawa, Yumiko
Shirota, Kinji
Moore, Peter F.
Nagata, Masahiko
author_facet Kondo, Hitoshi
Kagawa, Yumiko
Shirota, Kinji
Moore, Peter F.
Nagata, Masahiko
author_sort Kondo, Hitoshi
collection PubMed
description A 5‐year‐old, spayed female French Bulldog presented with multiple papules on the skin of the scapular area. Histopathological examination of punch biopsy samples revealed dense infiltration of small lymphoid cells in the superficial dermis and in areas surrounding hair follicles. Immunohistochemical analysis indicated that these cells were positive for CD3, CD4, and TCRαβ, but negative for CD1c, CD8α, CD8β, CD11c, CD20, CD45RA, CD90, MHC‐II, and TCRγδ. In addition, CD45 was highly expressed, and the proliferation fraction was very low. Molecular clonality of T‐cell receptor G chains yielded a clonal result. The skin lesions were surgically excised because they had progressed to the lateral front leg. Postoperative clinical course was favorable, and recurrence was not observed until the dog died in a traffic accident, approximately 1 year later.
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spelling pubmed-64989012019-05-07 Canine non‐epitheliotropic CD4‐positive cutaneous T‐cell lymphoma: a case report Kondo, Hitoshi Kagawa, Yumiko Shirota, Kinji Moore, Peter F. Nagata, Masahiko Vet Med Sci Case Report A 5‐year‐old, spayed female French Bulldog presented with multiple papules on the skin of the scapular area. Histopathological examination of punch biopsy samples revealed dense infiltration of small lymphoid cells in the superficial dermis and in areas surrounding hair follicles. Immunohistochemical analysis indicated that these cells were positive for CD3, CD4, and TCRαβ, but negative for CD1c, CD8α, CD8β, CD11c, CD20, CD45RA, CD90, MHC‐II, and TCRγδ. In addition, CD45 was highly expressed, and the proliferation fraction was very low. Molecular clonality of T‐cell receptor G chains yielded a clonal result. The skin lesions were surgically excised because they had progressed to the lateral front leg. Postoperative clinical course was favorable, and recurrence was not observed until the dog died in a traffic accident, approximately 1 year later. John Wiley and Sons Inc. 2018-12-12 /pmc/articles/PMC6498901/ /pubmed/30548472 http://dx.doi.org/10.1002/vms3.137 Text en © 2018 The Authors. Veterinary Medicine and Science Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Kondo, Hitoshi
Kagawa, Yumiko
Shirota, Kinji
Moore, Peter F.
Nagata, Masahiko
Canine non‐epitheliotropic CD4‐positive cutaneous T‐cell lymphoma: a case report
title Canine non‐epitheliotropic CD4‐positive cutaneous T‐cell lymphoma: a case report
title_full Canine non‐epitheliotropic CD4‐positive cutaneous T‐cell lymphoma: a case report
title_fullStr Canine non‐epitheliotropic CD4‐positive cutaneous T‐cell lymphoma: a case report
title_full_unstemmed Canine non‐epitheliotropic CD4‐positive cutaneous T‐cell lymphoma: a case report
title_short Canine non‐epitheliotropic CD4‐positive cutaneous T‐cell lymphoma: a case report
title_sort canine non‐epitheliotropic cd4‐positive cutaneous t‐cell lymphoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498901/
https://www.ncbi.nlm.nih.gov/pubmed/30548472
http://dx.doi.org/10.1002/vms3.137
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