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Spine SBRT With Halcyon™: Plan Quality, Modulation Complexity, Delivery Accuracy, and Speed

Purpose: Spine SBRT requires treatment plans with steep dose gradients and tight limits to the cord maximal dose. A new dual-layer staggered 1-cm MLC in Halcyon™ treatment platform has improved leakage, speed, and DLG compared to 120-Millennium (0.5-cm) and High-Definition (0.25-cm) MLCs in the True...

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Autores principales: Petroccia, Heather M., Malajovich, Irina, Barsky, Andrew R., Ghiam, Alireza Fotouhi, Jones, Joshua, Wang, Chunhao, Zou, Wei, Teo, Boon-Keng Kevin, Dong, Lei, Metz, James M., Li, Taoran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498946/
https://www.ncbi.nlm.nih.gov/pubmed/31106151
http://dx.doi.org/10.3389/fonc.2019.00319
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author Petroccia, Heather M.
Malajovich, Irina
Barsky, Andrew R.
Ghiam, Alireza Fotouhi
Jones, Joshua
Wang, Chunhao
Zou, Wei
Teo, Boon-Keng Kevin
Dong, Lei
Metz, James M.
Li, Taoran
author_facet Petroccia, Heather M.
Malajovich, Irina
Barsky, Andrew R.
Ghiam, Alireza Fotouhi
Jones, Joshua
Wang, Chunhao
Zou, Wei
Teo, Boon-Keng Kevin
Dong, Lei
Metz, James M.
Li, Taoran
author_sort Petroccia, Heather M.
collection PubMed
description Purpose: Spine SBRT requires treatment plans with steep dose gradients and tight limits to the cord maximal dose. A new dual-layer staggered 1-cm MLC in Halcyon™ treatment platform has improved leakage, speed, and DLG compared to 120-Millennium (0.5-cm) and High-Definition (0.25-cm) MLCs in the TrueBeam platform. Halcyon™ 2.0 with SX2 MLC modulates fluence with the upper and lower MLCs, while in Halcyon™ 1.0 with SX1 only the lower MLC modulates the fluence and the upper MLC functions as a back-up jaw. We investigated the effects of four MLC designs on plan quality for spine SBRT treatments. Methods: 15 patients previously treated at our institution were re-planned according to the NRG-BR-002 guidelines with a prescription of 3,000 cGy in 3 fractions, 6xFFF, 800 MU/min, and 3-arc VMAT technique. Planning objectives were adjusted manually by an experienced planner to generate optimal plans and kept the same for different MLCs within the same platform. Results: All treatment plans were able to achieve adequate target coverage while meeting NRG-BR002 dosimetric constraints. Planning parameters were evaluated including: conformity index, homogeneity index, gradient measure, and global point dose maximum. Delivery accuracy, modulation complexity, and delivery time were also analyzed for all MLCs. Conclusion: The Halcyon™ dual-layer MLC can generate comparable and clinically equivalent spine SBRT plans to TrueBeam plans with less rapid dose fall-off and lower conformity. MLC width leaf can impact maximum dose to organs at risk and plan quality, but does not cause limitations in achieving acceptable plans for spine SBRT treatments.
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spelling pubmed-64989462019-05-17 Spine SBRT With Halcyon™: Plan Quality, Modulation Complexity, Delivery Accuracy, and Speed Petroccia, Heather M. Malajovich, Irina Barsky, Andrew R. Ghiam, Alireza Fotouhi Jones, Joshua Wang, Chunhao Zou, Wei Teo, Boon-Keng Kevin Dong, Lei Metz, James M. Li, Taoran Front Oncol Oncology Purpose: Spine SBRT requires treatment plans with steep dose gradients and tight limits to the cord maximal dose. A new dual-layer staggered 1-cm MLC in Halcyon™ treatment platform has improved leakage, speed, and DLG compared to 120-Millennium (0.5-cm) and High-Definition (0.25-cm) MLCs in the TrueBeam platform. Halcyon™ 2.0 with SX2 MLC modulates fluence with the upper and lower MLCs, while in Halcyon™ 1.0 with SX1 only the lower MLC modulates the fluence and the upper MLC functions as a back-up jaw. We investigated the effects of four MLC designs on plan quality for spine SBRT treatments. Methods: 15 patients previously treated at our institution were re-planned according to the NRG-BR-002 guidelines with a prescription of 3,000 cGy in 3 fractions, 6xFFF, 800 MU/min, and 3-arc VMAT technique. Planning objectives were adjusted manually by an experienced planner to generate optimal plans and kept the same for different MLCs within the same platform. Results: All treatment plans were able to achieve adequate target coverage while meeting NRG-BR002 dosimetric constraints. Planning parameters were evaluated including: conformity index, homogeneity index, gradient measure, and global point dose maximum. Delivery accuracy, modulation complexity, and delivery time were also analyzed for all MLCs. Conclusion: The Halcyon™ dual-layer MLC can generate comparable and clinically equivalent spine SBRT plans to TrueBeam plans with less rapid dose fall-off and lower conformity. MLC width leaf can impact maximum dose to organs at risk and plan quality, but does not cause limitations in achieving acceptable plans for spine SBRT treatments. Frontiers Media S.A. 2019-04-26 /pmc/articles/PMC6498946/ /pubmed/31106151 http://dx.doi.org/10.3389/fonc.2019.00319 Text en Copyright © 2019 Petroccia, Malajovich, Barsky, Ghiam, Jones, Wang, Zou, Teo, Dong, Metz and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Petroccia, Heather M.
Malajovich, Irina
Barsky, Andrew R.
Ghiam, Alireza Fotouhi
Jones, Joshua
Wang, Chunhao
Zou, Wei
Teo, Boon-Keng Kevin
Dong, Lei
Metz, James M.
Li, Taoran
Spine SBRT With Halcyon™: Plan Quality, Modulation Complexity, Delivery Accuracy, and Speed
title Spine SBRT With Halcyon™: Plan Quality, Modulation Complexity, Delivery Accuracy, and Speed
title_full Spine SBRT With Halcyon™: Plan Quality, Modulation Complexity, Delivery Accuracy, and Speed
title_fullStr Spine SBRT With Halcyon™: Plan Quality, Modulation Complexity, Delivery Accuracy, and Speed
title_full_unstemmed Spine SBRT With Halcyon™: Plan Quality, Modulation Complexity, Delivery Accuracy, and Speed
title_short Spine SBRT With Halcyon™: Plan Quality, Modulation Complexity, Delivery Accuracy, and Speed
title_sort spine sbrt with halcyon™: plan quality, modulation complexity, delivery accuracy, and speed
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498946/
https://www.ncbi.nlm.nih.gov/pubmed/31106151
http://dx.doi.org/10.3389/fonc.2019.00319
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