Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours

Tumours defective in the DNA homologous recombination repair pathway can be effectively treated with poly (ADP-ribose) polymerase (PARP) inhibitors; these have proven effective in clinical trials in patients with BRCA gene function-defective cancers. However, resistance observed in both pre-clinical...

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Detalles Bibliográficos
Autores principales: Ordonez, Liliana D., Hay, Trevor, McEwen, Robert, Polanska, Urszula M., Hughes, Adina, Delpuech, Oona, Cadogan, Elaine, Powell, Steve, Dry, Jonathan, Tornillo, Giusy, Silcock, Lucy, Leo, Elisabetta, O’Connor, Mark J., Clarke, Alan R., Smalley, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498996/
https://www.ncbi.nlm.nih.gov/pubmed/31080552
http://dx.doi.org/10.18632/oncotarget.26830

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