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A case report of high-grade astroblastoma in a young adult

Astroblastoma is an uncommon neuroepithelial primary tumor of the brain which is of uncertain origin. We present a case of high-grade astroblastoma in an 18-year-old female with a severe headache, loss of appetite, vomiting and generalized weakness. The patient had undergone a right frontoparietal c...

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Autores principales: Bhalerao, Sagar, Nagarkar, Rajnish, Adhav, Aditya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499014/
https://www.ncbi.nlm.nih.gov/pubmed/30813777
http://dx.doi.org/10.2217/cns-2018-0012
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author Bhalerao, Sagar
Nagarkar, Rajnish
Adhav, Aditya
author_facet Bhalerao, Sagar
Nagarkar, Rajnish
Adhav, Aditya
author_sort Bhalerao, Sagar
collection PubMed
description Astroblastoma is an uncommon neuroepithelial primary tumor of the brain which is of uncertain origin. We present a case of high-grade astroblastoma in an 18-year-old female with a severe headache, loss of appetite, vomiting and generalized weakness. The patient had undergone a right frontoparietal craniotomy. Large subfalcine meningioma was excised. The lesion was suspected to be a meningioma. Primary radiological investigation revealed a 6.8 cm × 5.8 cm × 5.4 cm lesion. Although the radiological and intraoperative findings were of an extra-axial tumor, the histology and immunophenotype was of an astroblastoma. The patient was treated with cyclophosphamide, cisplatin and etoposide chemotherapy regimen. The patient was later treated with bi-weekly bevacizumab. The patient had improved symptomatically post-chemotherapy. However, there was no significant difference in lesion size. The patient died after 2 weeks. The prognosis of patients with astroblastoma is extremely poor as observed in our case.
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spelling pubmed-64990142019-05-06 A case report of high-grade astroblastoma in a young adult Bhalerao, Sagar Nagarkar, Rajnish Adhav, Aditya CNS Oncol Case Report Astroblastoma is an uncommon neuroepithelial primary tumor of the brain which is of uncertain origin. We present a case of high-grade astroblastoma in an 18-year-old female with a severe headache, loss of appetite, vomiting and generalized weakness. The patient had undergone a right frontoparietal craniotomy. Large subfalcine meningioma was excised. The lesion was suspected to be a meningioma. Primary radiological investigation revealed a 6.8 cm × 5.8 cm × 5.4 cm lesion. Although the radiological and intraoperative findings were of an extra-axial tumor, the histology and immunophenotype was of an astroblastoma. The patient was treated with cyclophosphamide, cisplatin and etoposide chemotherapy regimen. The patient was later treated with bi-weekly bevacizumab. The patient had improved symptomatically post-chemotherapy. However, there was no significant difference in lesion size. The patient died after 2 weeks. The prognosis of patients with astroblastoma is extremely poor as observed in our case. Future Medicine Ltd 2019-02-28 /pmc/articles/PMC6499014/ /pubmed/30813777 http://dx.doi.org/10.2217/cns-2018-0012 Text en © 2019 Dr Sagar Bhalerao This work is licensed under a Creative Commons Attribution-NonCommercial NonDerivative 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Case Report
Bhalerao, Sagar
Nagarkar, Rajnish
Adhav, Aditya
A case report of high-grade astroblastoma in a young adult
title A case report of high-grade astroblastoma in a young adult
title_full A case report of high-grade astroblastoma in a young adult
title_fullStr A case report of high-grade astroblastoma in a young adult
title_full_unstemmed A case report of high-grade astroblastoma in a young adult
title_short A case report of high-grade astroblastoma in a young adult
title_sort case report of high-grade astroblastoma in a young adult
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499014/
https://www.ncbi.nlm.nih.gov/pubmed/30813777
http://dx.doi.org/10.2217/cns-2018-0012
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