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A case report of high-grade astroblastoma in a young adult
Astroblastoma is an uncommon neuroepithelial primary tumor of the brain which is of uncertain origin. We present a case of high-grade astroblastoma in an 18-year-old female with a severe headache, loss of appetite, vomiting and generalized weakness. The patient had undergone a right frontoparietal c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Medicine Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499014/ https://www.ncbi.nlm.nih.gov/pubmed/30813777 http://dx.doi.org/10.2217/cns-2018-0012 |
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author | Bhalerao, Sagar Nagarkar, Rajnish Adhav, Aditya |
author_facet | Bhalerao, Sagar Nagarkar, Rajnish Adhav, Aditya |
author_sort | Bhalerao, Sagar |
collection | PubMed |
description | Astroblastoma is an uncommon neuroepithelial primary tumor of the brain which is of uncertain origin. We present a case of high-grade astroblastoma in an 18-year-old female with a severe headache, loss of appetite, vomiting and generalized weakness. The patient had undergone a right frontoparietal craniotomy. Large subfalcine meningioma was excised. The lesion was suspected to be a meningioma. Primary radiological investigation revealed a 6.8 cm × 5.8 cm × 5.4 cm lesion. Although the radiological and intraoperative findings were of an extra-axial tumor, the histology and immunophenotype was of an astroblastoma. The patient was treated with cyclophosphamide, cisplatin and etoposide chemotherapy regimen. The patient was later treated with bi-weekly bevacizumab. The patient had improved symptomatically post-chemotherapy. However, there was no significant difference in lesion size. The patient died after 2 weeks. The prognosis of patients with astroblastoma is extremely poor as observed in our case. |
format | Online Article Text |
id | pubmed-6499014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Future Medicine Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-64990142019-05-06 A case report of high-grade astroblastoma in a young adult Bhalerao, Sagar Nagarkar, Rajnish Adhav, Aditya CNS Oncol Case Report Astroblastoma is an uncommon neuroepithelial primary tumor of the brain which is of uncertain origin. We present a case of high-grade astroblastoma in an 18-year-old female with a severe headache, loss of appetite, vomiting and generalized weakness. The patient had undergone a right frontoparietal craniotomy. Large subfalcine meningioma was excised. The lesion was suspected to be a meningioma. Primary radiological investigation revealed a 6.8 cm × 5.8 cm × 5.4 cm lesion. Although the radiological and intraoperative findings were of an extra-axial tumor, the histology and immunophenotype was of an astroblastoma. The patient was treated with cyclophosphamide, cisplatin and etoposide chemotherapy regimen. The patient was later treated with bi-weekly bevacizumab. The patient had improved symptomatically post-chemotherapy. However, there was no significant difference in lesion size. The patient died after 2 weeks. The prognosis of patients with astroblastoma is extremely poor as observed in our case. Future Medicine Ltd 2019-02-28 /pmc/articles/PMC6499014/ /pubmed/30813777 http://dx.doi.org/10.2217/cns-2018-0012 Text en © 2019 Dr Sagar Bhalerao This work is licensed under a Creative Commons Attribution-NonCommercial NonDerivative 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Case Report Bhalerao, Sagar Nagarkar, Rajnish Adhav, Aditya A case report of high-grade astroblastoma in a young adult |
title | A case report of high-grade astroblastoma in a young adult |
title_full | A case report of high-grade astroblastoma in a young adult |
title_fullStr | A case report of high-grade astroblastoma in a young adult |
title_full_unstemmed | A case report of high-grade astroblastoma in a young adult |
title_short | A case report of high-grade astroblastoma in a young adult |
title_sort | case report of high-grade astroblastoma in a young adult |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499014/ https://www.ncbi.nlm.nih.gov/pubmed/30813777 http://dx.doi.org/10.2217/cns-2018-0012 |
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