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Angiotensin II Receptor 1 Blockage Limits Brain Damage and Improves Functional Outcome After Brain Injury in Aged Animals Despite Age-Dependent Reduction in AT1 Expression
Traumatic brain injury (TBI) is a frequent pathology associated with poor neurological outcome in the aged population. We recently observed accelerated cerebral inflammation in aged mice in response to TBI. Candesartan is a potent specific inhibitor of angiotensin II receptor type 1 (AT1) which limi...
Autores principales: | Timaru-Kast, Ralph, Gotthardt, Philipp, Luh, Clara, Huang, Changsheng, Hummel, Regina, Schäfer, Michael K. E., Thal, Serge C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499023/ https://www.ncbi.nlm.nih.gov/pubmed/31105549 http://dx.doi.org/10.3389/fnagi.2019.00063 |
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