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The TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP

Purpose: Mimetics based on Smac, the native inhibitor of XIAP, are promising drug-candidates for the treatment of cancer. Bivalent Smac mimetics inhibit XIAP with even higher potency than monovalent mimetics, but how to optimize the linker that tethers the two monovalent binding motifs remains contr...

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Detalles Bibliográficos
Autores principales:	Huang, Qingsheng, Peng, Yin, Peng, Yuefeng, Wei, Dan, Wei, Yanjie, Feng, Shengzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499140/ https://www.ncbi.nlm.nih.gov/pubmed/31118573 http://dx.doi.org/10.2147/DDDT.S194276

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