HES1, two programs: promoting the quiescence and proliferation of adult neural stem cells

Adult neural stem cells are mostly quiescent and only rarely enter the cell cycle to self-renew and generate neuronal or glial progenies. The Notch signaling pathway is essential for both the quiescent and proliferative states of neural stem cells. However, these are mutually exclusive cellular stat...

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Detalles Bibliográficos
Autores principales: Harris, Lachlan, Guillemot, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499324/
https://www.ncbi.nlm.nih.gov/pubmed/31043492
http://dx.doi.org/10.1101/gad.325761.119
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author Harris, Lachlan
Guillemot, François
author_facet Harris, Lachlan
Guillemot, François
author_sort Harris, Lachlan
collection PubMed
description Adult neural stem cells are mostly quiescent and only rarely enter the cell cycle to self-renew and generate neuronal or glial progenies. The Notch signaling pathway is essential for both the quiescent and proliferative states of neural stem cells. However, these are mutually exclusive cellular states; thus, how Notch promotes both of these programs within adult neural stem cells has remained unclear. In this issue of Genes & Development, Sueda and colleagues (pp. 511–523) use an extensive repertoire of mouse genetic tools and techniques to demonstrate that it is the levels and dynamic expression of the Notch transcriptional effector Hairy and Enhancer of Split 1 that enables this dual role.
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spelling pubmed-64993242019-11-01 HES1, two programs: promoting the quiescence and proliferation of adult neural stem cells Harris, Lachlan Guillemot, François Genes Dev Outlook Adult neural stem cells are mostly quiescent and only rarely enter the cell cycle to self-renew and generate neuronal or glial progenies. The Notch signaling pathway is essential for both the quiescent and proliferative states of neural stem cells. However, these are mutually exclusive cellular states; thus, how Notch promotes both of these programs within adult neural stem cells has remained unclear. In this issue of Genes & Development, Sueda and colleagues (pp. 511–523) use an extensive repertoire of mouse genetic tools and techniques to demonstrate that it is the levels and dynamic expression of the Notch transcriptional effector Hairy and Enhancer of Split 1 that enables this dual role. Cold Spring Harbor Laboratory Press 2019-05-01 /pmc/articles/PMC6499324/ /pubmed/31043492 http://dx.doi.org/10.1101/gad.325761.119 Text en © 2019 Harris and Guillemot; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Harris, Lachlan
Guillemot, François
HES1, two programs: promoting the quiescence and proliferation of adult neural stem cells
title HES1, two programs: promoting the quiescence and proliferation of adult neural stem cells
title_full HES1, two programs: promoting the quiescence and proliferation of adult neural stem cells
title_fullStr HES1, two programs: promoting the quiescence and proliferation of adult neural stem cells
title_full_unstemmed HES1, two programs: promoting the quiescence and proliferation of adult neural stem cells
title_short HES1, two programs: promoting the quiescence and proliferation of adult neural stem cells
title_sort hes1, two programs: promoting the quiescence and proliferation of adult neural stem cells
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499324/
https://www.ncbi.nlm.nih.gov/pubmed/31043492
http://dx.doi.org/10.1101/gad.325761.119
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