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Urinary trimethyl tin reflects blood trimethyl tin in workers recycling organotins
AIM: Our recent case report of organotin intoxication showed higher ratio of urinary trimethyl tin (TMT) to dimethyl tin (DMT) than those of the previous cases exposed to only DMT, suggesting co‐exposure to DMT and TMT occurred. The present study investigated how urinary TMT and DMT reflect blood TM...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499364/ https://www.ncbi.nlm.nih.gov/pubmed/30924213 http://dx.doi.org/10.1002/1348-9585.12052 |
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author | Ichihara, Gaku Iida, Mayu Watanabe, Eri Fujie, Tomoya Kaji, Toshiyuki Lee, Eunmi Kim, Yangho |
author_facet | Ichihara, Gaku Iida, Mayu Watanabe, Eri Fujie, Tomoya Kaji, Toshiyuki Lee, Eunmi Kim, Yangho |
author_sort | Ichihara, Gaku |
collection | PubMed |
description | AIM: Our recent case report of organotin intoxication showed higher ratio of urinary trimethyl tin (TMT) to dimethyl tin (DMT) than those of the previous cases exposed to only DMT, suggesting co‐exposure to DMT and TMT occurred. The present study investigated how urinary TMT and DMT reflect blood TMT and DMT, respectively, to evaluate them as biomarkers for TMT/DMT exposure. METHODS: DMT and TMT from blood collected at different time points from three patients intoxicated with organotins were measured with HPLC‐ICP/MS. Previously published data of urinary DMT and TMT were used for comparison. Regression analyses were conducted with dependent variable of blood DMT and TMT and independent variable of urinary DMT and TMT, respectively. Multiple regression analysis with dummy variables of individual was also conducted. RESULTS: Regression analysis did not show significant relation of urinary TMT to blood TMT or relation of urinary DMT to blood DMT, although the former was marginal. Multiple regression analysis showed significantly positive relation of urinary TMT to blood TMT. CONCLUSIONS: The study shows that urinary TMT reflects blood TMT. In co‐exposure to TMT and DMT, urinary TMT can be an internal exposure marker of TMT, which might be not only derived from external exposure to TMT but also converted from DMT in human body. |
format | Online Article Text |
id | pubmed-6499364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64993642019-05-07 Urinary trimethyl tin reflects blood trimethyl tin in workers recycling organotins Ichihara, Gaku Iida, Mayu Watanabe, Eri Fujie, Tomoya Kaji, Toshiyuki Lee, Eunmi Kim, Yangho J Occup Health Brief Reports AIM: Our recent case report of organotin intoxication showed higher ratio of urinary trimethyl tin (TMT) to dimethyl tin (DMT) than those of the previous cases exposed to only DMT, suggesting co‐exposure to DMT and TMT occurred. The present study investigated how urinary TMT and DMT reflect blood TMT and DMT, respectively, to evaluate them as biomarkers for TMT/DMT exposure. METHODS: DMT and TMT from blood collected at different time points from three patients intoxicated with organotins were measured with HPLC‐ICP/MS. Previously published data of urinary DMT and TMT were used for comparison. Regression analyses were conducted with dependent variable of blood DMT and TMT and independent variable of urinary DMT and TMT, respectively. Multiple regression analysis with dummy variables of individual was also conducted. RESULTS: Regression analysis did not show significant relation of urinary TMT to blood TMT or relation of urinary DMT to blood DMT, although the former was marginal. Multiple regression analysis showed significantly positive relation of urinary TMT to blood TMT. CONCLUSIONS: The study shows that urinary TMT reflects blood TMT. In co‐exposure to TMT and DMT, urinary TMT can be an internal exposure marker of TMT, which might be not only derived from external exposure to TMT but also converted from DMT in human body. John Wiley and Sons Inc. 2019-03-28 /pmc/articles/PMC6499364/ /pubmed/30924213 http://dx.doi.org/10.1002/1348-9585.12052 Text en © 2019 The Authors. Journal of Occupational Health published by John Wiley & Sons Australia, Ltd on behalf of The Japan Society for Occupational Health This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Brief Reports Ichihara, Gaku Iida, Mayu Watanabe, Eri Fujie, Tomoya Kaji, Toshiyuki Lee, Eunmi Kim, Yangho Urinary trimethyl tin reflects blood trimethyl tin in workers recycling organotins |
title | Urinary trimethyl tin reflects blood trimethyl tin in workers recycling organotins |
title_full | Urinary trimethyl tin reflects blood trimethyl tin in workers recycling organotins |
title_fullStr | Urinary trimethyl tin reflects blood trimethyl tin in workers recycling organotins |
title_full_unstemmed | Urinary trimethyl tin reflects blood trimethyl tin in workers recycling organotins |
title_short | Urinary trimethyl tin reflects blood trimethyl tin in workers recycling organotins |
title_sort | urinary trimethyl tin reflects blood trimethyl tin in workers recycling organotins |
topic | Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499364/ https://www.ncbi.nlm.nih.gov/pubmed/30924213 http://dx.doi.org/10.1002/1348-9585.12052 |
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