LncRNA DILC participates in rheumatoid arthritis by inducing apoptosis of fibroblast-like synoviocytes and down-regulating IL-6

IL-6 produced by human fibroblast-like synoviocytes (HFLS) promotes rheumatoid arthritis (RA), while lncRNA DILC regulates liver cancer stem cells by inhibiting IL-6. Therefore, lncRNA DILC may participate in RA. In the present study, we found that plasma lncRNA DILC was down-regulated, while IL-6 w...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Guan, Tang, Lian, Zhang, Xihai, Li, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499449/
https://www.ncbi.nlm.nih.gov/pubmed/30944206
http://dx.doi.org/10.1042/BSR20182374
_version_ 1783415793792319488
author Wang, Guan
Tang, Lian
Zhang, Xihai
Li, Yao
author_facet Wang, Guan
Tang, Lian
Zhang, Xihai
Li, Yao
author_sort Wang, Guan
collection PubMed
description IL-6 produced by human fibroblast-like synoviocytes (HFLS) promotes rheumatoid arthritis (RA), while lncRNA DILC regulates liver cancer stem cells by inhibiting IL-6. Therefore, lncRNA DILC may participate in RA. In the present study, we found that plasma lncRNA DILC was down-regulated, while IL-6 was up-regulated in RA patients than in healthy controls. Plasma levels of lncRNA DILC and IL-6 were significantly and inversely correlated only in RA patients. Overexpression of lncRNA DILC resulted in promoted apoptosis of HFLS isolated from RA patients, while lncRNA DILC siRNA silencing played an opposite role. In addition, overexpression of lncRNA DILC also resulted in inhibited IL-6 expression in HFLS isolated from RA patients. Therefore, lncRNA DILC may participate in RA by inducing apoptosis of HFLS and down-regulating IL-6.
format Online
Article
Text
id pubmed-6499449
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-64994492019-05-16 LncRNA DILC participates in rheumatoid arthritis by inducing apoptosis of fibroblast-like synoviocytes and down-regulating IL-6 Wang, Guan Tang, Lian Zhang, Xihai Li, Yao Biosci Rep Research Articles IL-6 produced by human fibroblast-like synoviocytes (HFLS) promotes rheumatoid arthritis (RA), while lncRNA DILC regulates liver cancer stem cells by inhibiting IL-6. Therefore, lncRNA DILC may participate in RA. In the present study, we found that plasma lncRNA DILC was down-regulated, while IL-6 was up-regulated in RA patients than in healthy controls. Plasma levels of lncRNA DILC and IL-6 were significantly and inversely correlated only in RA patients. Overexpression of lncRNA DILC resulted in promoted apoptosis of HFLS isolated from RA patients, while lncRNA DILC siRNA silencing played an opposite role. In addition, overexpression of lncRNA DILC also resulted in inhibited IL-6 expression in HFLS isolated from RA patients. Therefore, lncRNA DILC may participate in RA by inducing apoptosis of HFLS and down-regulating IL-6. Portland Press Ltd. 2019-05-02 /pmc/articles/PMC6499449/ /pubmed/30944206 http://dx.doi.org/10.1042/BSR20182374 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Wang, Guan
Tang, Lian
Zhang, Xihai
Li, Yao
LncRNA DILC participates in rheumatoid arthritis by inducing apoptosis of fibroblast-like synoviocytes and down-regulating IL-6
title LncRNA DILC participates in rheumatoid arthritis by inducing apoptosis of fibroblast-like synoviocytes and down-regulating IL-6
title_full LncRNA DILC participates in rheumatoid arthritis by inducing apoptosis of fibroblast-like synoviocytes and down-regulating IL-6
title_fullStr LncRNA DILC participates in rheumatoid arthritis by inducing apoptosis of fibroblast-like synoviocytes and down-regulating IL-6
title_full_unstemmed LncRNA DILC participates in rheumatoid arthritis by inducing apoptosis of fibroblast-like synoviocytes and down-regulating IL-6
title_short LncRNA DILC participates in rheumatoid arthritis by inducing apoptosis of fibroblast-like synoviocytes and down-regulating IL-6
title_sort lncrna dilc participates in rheumatoid arthritis by inducing apoptosis of fibroblast-like synoviocytes and down-regulating il-6
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499449/
https://www.ncbi.nlm.nih.gov/pubmed/30944206
http://dx.doi.org/10.1042/BSR20182374
work_keys_str_mv AT wangguan lncrnadilcparticipatesinrheumatoidarthritisbyinducingapoptosisoffibroblastlikesynoviocytesanddownregulatingil6
AT tanglian lncrnadilcparticipatesinrheumatoidarthritisbyinducingapoptosisoffibroblastlikesynoviocytesanddownregulatingil6
AT zhangxihai lncrnadilcparticipatesinrheumatoidarthritisbyinducingapoptosisoffibroblastlikesynoviocytesanddownregulatingil6
AT liyao lncrnadilcparticipatesinrheumatoidarthritisbyinducingapoptosisoffibroblastlikesynoviocytesanddownregulatingil6

Ejemplares similares