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APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma

Recent studies have revealed the mutational signatures underlying the somatic evolution of cancer, and the prevalences of associated somatic genetic variants. Here we estimate the intensity of positive selection that drives mutations to high frequency in tumors, yielding higher prevalences than expe...

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Detalles Bibliográficos
Autores principales:	Cannataro, Vincent L., Gaffney, Stephen G., Sasaki, Tomoaki, Issaeva, Natalia, Grewal, Nicholas K. S., Grandis, Jennifer R., Yarbrough, Wendell G., Burtness, Barbara, Anderson, Karen S., Townsend, Jeffrey P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499643/ https://www.ncbi.nlm.nih.gov/pubmed/30647454 http://dx.doi.org/10.1038/s41388-018-0657-6

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