Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells

Haematopoietic stem cells (HSCs) are maintained by bone marrow (BM) niches in vivo(1,2), but the ability of niche cells to maintain HSCs ex vivo is markedly diminished. Expression of niche factors by Nestin-GFP(+) mesenchymal-derived stromal cells (MSCs) is downregulated upon culture, suggesting tha...

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Detalles Bibliográficos
Autores principales: Nakahara, Fumio, Borger, Daniel K., Wei, Qiaozhi, Pinho, Sandra, Maryanovich, Maria, Zahalka, Ali H., Suzuki, Masako, Cruz, Cristian D., Wang, Zichen, Xu, Chunliang, Boulais, Philip E., Ma'ayan, Avi, Greally, John M., Frenette, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499646/
https://www.ncbi.nlm.nih.gov/pubmed/30988422
http://dx.doi.org/10.1038/s41556-019-0308-3

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