Effect of a phosphodiesterase-5A (PDE5A) gene polymorphism on response to sildenafil therapy in canine pulmonary hypertension

Pulmonary hypertension (PH) is a common clinical condition associated with morbidity and mortality in both humans and dogs. Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor causing accumulation of cGMP, is frequently used for treatment of PH. The authors previously reported a PDE5A:E90K polymorphi...

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Detalles Bibliográficos
Autores principales: Ueda, Yu, Johnson, Lynelle R., Ontiveros, Eric S., Visser, Lance C., Gunther-Harrington, Catherine T., Stern, Joshua A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499771/
https://www.ncbi.nlm.nih.gov/pubmed/31053768
http://dx.doi.org/10.1038/s41598-019-43318-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499771/
https://www.ncbi.nlm.nih.gov/pubmed/31053768
http://dx.doi.org/10.1038/s41598-019-43318-z

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